Browsing by Author "Fareid, Mohamed A"

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Echinops spinosus effect against diabetes and its hepatorenal complications: total extract and flavonoids fraction
(Springer, 26/01/2022) Othman, Mohamed S; Khaled, Azza M; Al‑Bagawi, Amal H; Fareid, Mohamed A; Hameed, Reda A; Abu Zahra, Fatama A; Abdel Moneim, Ahmed E
Download PDF Download PDF Research Article Published: 26 January 2022 Echinops spinosus effect against diabetes and its hepatorenal complications: total extract and flavonoids fraction Mohamed S. Othman, Azza M. Khaled, …Ahmed E. Abdel Moneim Show authors Environmental Science and Pollution Research (2022)Cite this article 4 Accesses Metricsdetails Abstract The perennial plant Echinops spinosus (ES) grows in the Hail area of Saudi Arabia, and its traditional formulations are often employed in folk medicine. The goal of this study is to identify the active components present in Hail Echinops spinosus and to investigate the anti-diabetic properties of both ES total extract (ESTE) and its high flavonoids fraction (ESHFF) in experimental diabetes induced by streptozotocin (STZ) injection in rats. Forty-two rats were divided into six groups. Diabetes was induced using STZ (55 mg/kg). Seven days after STZ administration, the diabetic animals were treated daily with ESTE, ESHFF, or metformin (MET) as a standard anti-diabetic drug for 28 days. Blood and tissues samples were collected for biochemical, molecular, and histological investigations. Both ESTE and ESHFF demonstrated anti-diabetic properties, as evidenced by lowering glucose levels and increasing the levels of insulin, insulin receptor expression rate, and glycogen synthesis. Additionally, ESTE as well as ESHFF alleviated diabetic complications in the kidneys and liver by decreasing oxidative stress, modulating inflammatory mediators, and suppressing the apoptotic cascade along with correcting diabetic dyslipidemia. It could be deduced that Hail ES extracts could play a role in the treatment of type 2 diabetes and diabetes-related lesions as well as oxidative damage in hepatic and renal tissues.
Evaluation of antiobesity and hepatorenal protective activities of Salvia ofcinalis extracts pre‑treatment in high‑fat diet‑induced obese rats
(Springer Science, 01/06/2022) Othman, Mohamed S; Khaled, Azza M; Aleid, Ghada M; Fareid, Mohamed A; Hameed, Reda A; Abdelfattah, Mohamed S; Ezz Aldin, Doaa ; Abdel Moneim, Ahmed E
The present study evaluated the efects of Hail Salvia ofcinalis total extract (SOTE) and its high favonoid fraction (SOHFF) on the high-fat diet (HFD)-induced obesity and hepatorenal damage in rats. Salvia ofcinalis plants were collected from Hail region, Saudi Arabia. Rats were fed HFD and supplemented orally with SOTE (250 mg kg−1) or SOHFF (100 mg kg−1) or simvastatin (SVS; 10 mg kg−1) every day for 8 weeks. Compared to the controls, HFD-induced obesity led to signifcant increases in body weight, body weight gained, blood insulin, leptin, cardiac enzymes (LDH and CPK) activity, and athero- genic index (AI). HFD rats also showed higher levels of hepatic and renal function biomarkers (ALT, urea, and creatinine), as well as lower levels of PPARγ and Nrf2-gene expression and a disrupted lipid profle. Moreover, HFD rats had lower levels of hepatic and renal antioxidant biomarkers (CAT, GPx, SOD, GR, and GSH), accompanied by higher levels of hepatic and renal lipid peroxidation (LPO), nitric oxide (NO), and infammatory mediators (interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α)). In addition, histological examination of hepatic and renal tissues revealed histopathological changes that validated the biochemical fndings. Compared to HFD group, SOTE and SOHFF treatment led to marked amelioration of all the aforementioned parameters. Collectively, supplementation with SOTE and SOHFF efectively reversed HFD-induced alterations through its antioxidant, hypolipidemic, and anti-infammatory properties. Hence, SOTE and SOHFF have thera- peutic potential in controlling obesity and related pathologies.