Browsing by Author "Ezzat, Shahira M"

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Green hydrogen as a source of renewable energy: a step towards sustainability, an overview
(Springer Netherlands, 2024-05) Reda, Bassma ; Elzamar, Amr A; AlFazzani, Shehab ; Ezzat, Shahira M
Hydrogen has emerged as a promising energy source for a cleaner and more sustainable future due to its clean-burning nature, versatility, and high energy content. Moreover, hydrogen is an energy carrier with the potential to replace fossil fuels as the primary source of energy in various industries. In this review article, we explore the potential of hydrogen as a part of the global energy mix and the current state of its development. The majority of hydrogen production currently occurs through steam methane reforming, which produces signifcant greenhouse gas emissions and limits the potential of hydrogen as a clean energy source. Signifcant investment and advancements in renewable hydrogen production through electrolysis are necessary to overcome this limitation. There is also a growing demand for hydrogen infrastructure, including hydrogen refueling stations and storage and transportation systems, which are crucial for the growth and success of the hydrogen industry. The future of hydrogen as a part of the global energy mix will depend on continued investment and commitment to develop and commercialize this promising energy source. Our review also explores the relationship between eco-industrial parks and hydrogen production, including the benefts and challenges of hydrogen production in EIPs and the various technologies being developed to facilitate this process.
Isolation of secondary metabolites from the mediterranean sponge species; Hemimycale columella and its biological properties
(Springer Nature, 12/22/2020) Marmouzi, Ilias ; Ezzat, Shahira M; Mostafa, Eman Sherien ; El Jemli, Meryem ; Radwan, Rasha Ali ; Faouzi, My El Abbes ; Tamsouri, Naoufal ; Kharbach, Mourad
Despite the richness and biodiversity of invertebrates and algae in the Mediterranean Sea, these organisms are still poorly studied. The objective of our research is the discovery of bioactive lead compounds from the Mediterranean Sea sponge Hemimycale Collumella (HC). HC sponge (189.0 g) was collected from Mdiq costs on the Mediterranean Sea and extracted with methanol to yield (10 g) which was then subjected to fractionation. A bio-guided protocol was applied through evaluation of 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging and Oxygen Radical Absorbance Capacity (ORAC), α-amylase, β-glucosidase, pancreatic lipase inhibition as well as anti-collagenase, anti-elastase, antityrosinase and cytotoxic activity. 2,3-O-Hexahydroxydiphenoyl-(α/β)-glucose (1) and gentisic acid 2-O-β-glucoside (2) were isolated from the water fraction, quercetin-3-O-β-glucopyranoside (3), kaempferol 3-O-β-glucopyranoside (4) and isorhamnetin 3-O-β-glucopyranoside (5) from n-butanol fraction, gallic acid (6) from ethyl acetate fraction and gallic acid-3-methyl ether (7) from methylene chloride fraction. Compound 5 had the highest DPPH and ORAC activity. Compounds 1–5 had promising lipase inhibition activities which exceeded that of the standard Orlistat, while compounds 1–7 showed anti-tyrosinase activity higher than that of the standard Hydroquinone monomethyl ether. This is the first report for evaluation of the biological activities of 2, 3-O-hexahydroxydiphenoyl-(α/β)-glucose (1), gentisic acid 2-O-β-glucoside (2) and gallic acid-3-methyl ether (7).
Pharmacological properties of mangiferin: bioavailability, mechanisms of action and clinical perspectives
(Springer Verlag, 2023-08) Zivković, Jelena ; Kumar, Kammala Ananth ; Rushendran, Rapuru ; Ilango, Kaliappan ; Fahmy, Nouran M; El‑Nashar, Heba A. S; El‑Shazly, Mohamed ; Ezzat, Shahira M; Melgar‑Lalanne, Guiomar ; Romero‑Montero, Alejandra ; Peña‑Corona, Sheila I; Leyva‑Gomez, Gerardo ; Sharif‑Rad, Javad ; Calina, Daniela
This review aims to provide an in-depth analysis of the pharmacological properties of mangiferin, focusing primarily on its bioavailability and mechanisms of action, and its potential therapeutic applications, especially in the context of chronic diseases. We conducted a comprehensive examination of in vitro and in vivo studies, as well as clinical trials involving man- giferin or plant extracts containing mangiferin. The primary source of mangiferin is Mangifera indica, but it’s also found in other plant species from the families Anacardiaceae, Gentianaceae, and Iridaceae. Mangiferin has exhibited a myriad of therapeutic properties, presenting itself as a promising candidate for treating various chronic conditions including neurode- generative disorders, cardiovascular diseases, renal and pulmonary diseases, diabetes, and obesity. Despite the promising results showcased in many in vitro studies and certain animal studies, the application of mangiferin has been limited due to its poor solubility, absorption, and overall bioavailability. Mangiferin ofers signifcant therapeutic potential in treating a spectrum of chronic diseases, as evidenced by both in vitro and clinical trials. However, the challenges concerning its bio- availability necessitate further research, particularly in optimizing its delivery and absorption, to harness its full medicinal potential. This review serves as a comprehensive update on the health-promoting and therapeutic activities of mangiferin.
Roles of Nanotechnology for Effcient Nutrient Delivery of Foods
(Springer nature, 04/05/2022) Ezzat, Shahira M; Salama, Maha ; El Mahdi, Nehal; Salem, Mohamed
Nanotechnology involves the use of materials in the nanoscale for different purposes. Applications of nanotechnology in food science and food industry is a fast growing area nowadays. These applications involves the use of nanomaterials in food coatings to protect the food from moisture and microorganisms, the use of stronger flavors and coloring nanomaterials to improve the appearance and taste of food, to facilitate delivery of nutrients and most widely the nanometerials are used in packaging of food. Despite the advance in the applications of nanotechnology of food, still large number of publics refuse to use such processed food especially that there are few studies on the safety and toxicity of such products. In our chapter we will have an overview on food grade and non-food grade nanoparticles that are used for nutraceutical delivery in addition to the health hazards related to nanomaterials.
An Updated Review on Glycoprotein IIb/IIIa Inhibitors as Antiplatelet Agents: Basic and Clinical Perspectives
(Adis International Ltd, 2023-01) Sharif‑Rad, Javad ; Sharopov, Farukh ; Ezzat, Shahira M; Zam, Wissam ; Ademiluyi, Adedayo Oluwaseun ; Oyeniran, Olubukola Helen ; Adetunji, Charles Oluwaseun ; Roli, Osahon Itohan ; Živković, Jelena ; Martorell, Miquel ; Docea, Anca Oana ; El Omari, Nasreddine ; Bouyahya, Abdelhakim ; Lorenzo, José M; Calina, Daniela
The glycoprotein (GP) IIb/IIIa receptor is found integrin present in platelet aggregations. GP IIb/IIIa antagonists interfere with platelet cross-linking and platelet-derived thrombus formation through the competition with fbrinogen and von Wille- brand factor. Currently, three parenteral GP IIb/IIIa competitors (tirofban, eptifbatide, and abciximab) are approved for clinical use in patients afected by percutaneous coronary interventions (PCI) in the location of acute coronary syndrome (ACS). GP IIb/IIIa antagonists have their mechanism of action in platelet aggregation prevention, distal thromboembolism, and thrombus formation, whereas the initial platelet binding to damage vascular areas is preserved. This work is aimed to provide a comprehensive review of the signifcance of GP IIb/IIIa inhibitors as a sort of antiplatelet agent. Their mechanism of action is based on factors that afect their efcacy. On the other hand, drugs that inhibit GP IIb/IIIa already approved by the FDA were reviewed in detail. Results from major clinical trials and regulatory practices and guidelines to deal with GP IIb/IIIa inhibitors were deeply investigated. The cardiovascular pathology and neuro-interventional surgical application of GP IIb/IIIa inhibitors as a class of antiplatelet agents were developed in detail. The therapeutic risk/beneft balance of cur- rently available GP IIb/IIa receptor antagonists is not yet well elucidated in patients with ACS who are not clinically evalu- ated regularly for early cardiovascular revascularization. On the other hand, in patients who have benefted from PCI, the antiplatelet therapy intensifcation by the addition of a GP IIb/IIIa receptor antagonist (intravenously) may be an appropriate therapeutic strategy in reducing the occurrence of risks of thrombotic complications related to the intervention. Development of GP IIb/IIIa inhibitors with oral administration has the potential to include short-term antiplatelet benefts compared with intravenous GP IIb/IIIa inhibitors for long-term secondary preventive therapy in cardiovascular disease. But studies showed that long-term oral administration of GP IIb/IIIa receptor inhibitors has been inefective in preventing ischemic events. Paradoxically, they have been linked to a high risk of side efects by producing prothrombotic and pro-infammatory events.
Validation of Anti‑pyretic‑Derived Natural Products and Their Potentials for Drug Discovery
(Springer Nature Switzerland AG, 2023-05) Zayed, Ahmed ; Salem, Mohamed A; Negm, Walaa A; Ezzat, Shahira M
Fever is a complicated process that occurs in response to infection and infammatory diseases, stimulating the immune system that may cause severe biological changes in the human body. Hence, anti-pyretic agents are prescribed to reduce elevated body temperature in order to maintain thermal homeostasis and protect the brain from damage. Additionally, there is always a growing need for safe and efective anti-pyretic drugs derived from natural products, especially that anti-pyretic pathways have been investigated well in previous literature. Many animal models are established for assessing anti-pyretic candidates resulting in two types of anti-pyretics. They are the endogenous anti-pyretics that act as a defense mechanism for temperature regulation and the exogenous anti-pyretics. The current article discusses the main anti-pyretic pathways, models for assessing anti-pyretics, metabolomics applications in anti-pyretic assays, and screening of anti-pyretic and analgesic natural products. Screening of plant-derived natural products and active principles with anti-pyretic, anti-infammatory, and analgesic activities, in addition to their mechanism of action and validation methods, is described in the current article. Hence, this review could contribute to the introduction of a site-specifc and safe naturally derived anti-pyretic medications with potential therapeutic qualities compared to currently available synthetic anti-pyretics.
Valorization of by‑products Derived from Onions and Potato: Extraction Optimization, Metabolic Profle, Outstanding Bioactivities, and Industrial Applications
(Springer Netherlands, 2023-01) Salem, Mohamed A; Abo Mansour, Hend E; Mosalam, Esraa M; El‑Shiekh, Riham A; Ezzat, Shahira M; Zayed, Ahmed
Huge quantities of vegetables and fruits by-products are discarded annually worldwide following the industrial food pro- cessing techniques. These biowastes were found to cause further environmental hazards. However, they could represent rich sources of numerous bioactive metabolites and substrates for high valued products. Specifcally, onion (Allium cepa L.) and potato (Solanum tuberosum L.) are of economic importance since they are cultivated and found as chief components of most food recipes worldwide. Nevertheless, potato peels and the outer onion scaly leaves are major non-edible by-products. Both biowastes are rich in bioactive phenolic compounds, whereas potato peels are rich in chlorogenic acids and onion solid wastes in favonoids, particularly favonols (quercetin derivatives). Also, they are good sources of dietary fbers, fatty acids, starches, sugars and proteins. In addition, they are potential candidates for biofuels production. Hence, with the recent advances of bio-refnery concepts valorization of such treasures is highly recommended. The current review highlighted the major metabolic classes of onion and potato agro-industrial wastes and how we can utilize the available possibilities to maximize the recovery and benefts of metabolites found in these wastes.