Browsing by Author "Essam, Abdelrahman"
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Item Efficacy of the aqueous extract of Siwa dates in protection against the whole body γ irradiation induced damages in mice(Taylor and Francis Ltd., 2021-08) Farid, Alyaa; Haytham, Merna; Essam, Abdelrahman; Safwat, GehanIonizing radiation hydrolyzes H2O and leads to free radicals production that initiates inflammation an DNA amages. Siwa ates are an important crop in Egypt that has been use as a staple foo ue to its nutritional value an its antioxiant properties. The stuy aime to investigate the raioprotective effects of aqueous extract of Siwa ates in whole boy γ- irraiate mice. Animals were ivie into four groups: healthy mice, unirraiate mice that receive Siwa ate aqueous extract, irraiate unprotecte mice an irraiate mice that receive aily 4 ml/kg Siwa ate extract for 14 ays prior to irraiation. Twenty four hours post irraiation, bloo an liver samples were collecte for immunological, biochemical, anhistopathological stuies. Apoptosis an apoptotic proteins in hepatocytes were measure by flow cytometry techniques. Moreover, the cytokinesis-blocke micronucleus assay was performe to measure DNA amages. Matrix metalloproteinases (MMPs) were evaluate in liver samples by both ELISA an immunohistochemical techniques. The results have shown the improvement in liver histopathological sections an the amelioration in the pro-inflammatory cascae. Siwa ate extract allowe DNA protection from the estructive effect of irraiation. In conclusion, Siwa ates were effective in alleviating raiation inuce amages such as hepatotoxicity, oxiative stress, inflammation, an DNA amage.