Browsing by Author "El-Zahaby, Sally A"

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    Norfloxacin loaded nano-cubosomes for enhanced management of otitis externa: in vitro and in vivo evaluation
    (Elsevier, 3/17/2021) Al-mahallawi, Abdulaziz M; Abdelbary, Aly A; El-Zahaby, Sally A
    The research’s goal is to design and formulate nano-structured cubosomes loaded with norfloxacin (NFX) for management of otitis externa. In this study, glyceryl monooleate (GMO) as lipid phase, Cremophor EL as surfactant and either Pluronic F108 or Pluronic F127 as stabilizer were the used ingredients. The nano-cubosomal formulation “CUB 1” (95% of GMO, 2.5% of Cremophor EL and 2.5% of Pluronic F108) was the best achieved one. It had small particles size (216.75 ±2.47 nm), good polydispersity index (0.339±0.012) and acceptable zeta potential (-41.2±2.262 mV). Images obtained after transmission electron microscopy examination ensured nearly cubic shape of formed nanoparticles with excellent dispersibility. Moreover, micrographs of rabbit ear skin specimens examined by confocal laser microscopy ensured good permeation capability of CUB1. In addition, in vivo skin deposition results revealed that higher amount of NFX was deposited in the rabbit ear skin throughout the study period (10 h) compared to drug suspension. Additionally, histopathological results proved that NFX loaded cubosomes can be safely applied topically on ear skin without any signs of inflammation nor skin irritation. Accordingly, these results anticipated the nano-structured cubosomal capabilities as a favorable nano-carrier for dermal NFX delivery to external ear skin for enhancing the management of otitis externa.
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    Potential therapeutic and pharmacological strategies for SARS-CoV2
    (Springer, 03/05/2021) Ghareeb, Doaa A; Saleh, Samar R; Nofal, Mohammed S; Kaddah, Mohamed M. Y; Hassan, Salma. F; Seif, Inas K; El-Zahaby, Sally A; Khedr, Shaimaa M; Kenawy, Marwa Y; Masoud, Aliaa A; Soudi, Salma A; Sobhy, Ahmed A; Sery, Jaillan G; Abd El-Wahab, Miral G; Abd Elmoneam, Alshimaa A; Al-mahallawi, Abdulaziz Mohsen; El-Demellawy, Maha A
    Background At the end of 2019, the new Coronavirus disease 2019 (COVID-19) strain causing severe acute respiratory syndrome swept the world. From November 2019 till February 2021, this virus infected nearly 104 million, with more than two million deaths and about 25 million active cases. This has prompted scientists to discover efective drugs to combat this pandemic. Area covered Drug repurposing is the magic bullet for treating severe acute respiratory syndrome coronavirus 2 (SARS￾CoV2). Therefore, several drugs have been investigated in silico, in vitro, as well as through human trials such as anti￾SARS-CoV2 agents, or to prevent the complications resulting from the virus. In this review, the mechanisms of action of diferent therapeutic strategies are summarized. According to the WHO, diferent classes of drugs can be used, including anti-malarial, antiviral, anti-infammatory, and anti-coagulant drugs, as well as angiotensin-converting enzyme inhibitors, antibiotics, vitamins, zinc, neutralizing antibodies, and convalescent plasma therapy. Recently, there are some vaccines which are approved against SARS-CoV2. Expert opinion A complete understanding of the structure and function of all viral proteins that play a fundamental role in viral infection, which contribute to the therapeutic intervention and the development of vaccine in order to reduce the mortality rate.