Browsing by Author "El-Gendy, Zeinab A"

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    Assessment of Lavender, Frankincense and Peppermint Oils Trans-dermal Nano Spray Formulation Effect on Wound Healing Activity in Rat Model
    (National Information and Documentation Centre, 2024-11) Safwat, Gehan; El-Gendy, Zeinab A; Ramadan, Lamiaa M; Fathy, Hager N; Ezzo, Omaima H; Rostom, Merit; Fouda, Fayez K
    Burns are one of the leading causes of mortality and high morbidity, particularly when combined with bacterial infection that prevents wound closure and delays the healing process. Consequently, there is a huge demand for pharmaceutical techniques to assist in resolving this problem. Essential oils are becoming more popular as organic substitutes for synthetic medications. However, the usage of essential oils is limited due to their poor qualities but they can be utilized by encapsulating them in Nano emulsions. The aim of this study is to investigate the Nano spray formulation containing a combination of lavender, frankincense and peppermint oils for burn healing potential using rat-burn induced model. The effect of Nano emulsions of 2% lavender, 10% peppermint, 5% frankincense, the combination of the three oils in half of their concentrations and the combination in the same concentrations on the fibrotic marker, oxidative stress markers, and histopathological was examined. Our results support the use of essential oils in the development of pharmaceuticals for wounds management and/or inflammatory-related diseases. A trans-dermal Nano spray formulation containing a combination of lavender, frankincense and peppermint oils exhibit considerable wound healing activity.
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    Hepatoprotective effect of Omega-3 PUFAs against acute paracetamol- induced hepatic injury confirmed by FTIR
    (SAGE, 2020) El-Gendy, Zeinab A; El-Batran, Seham A; Youssef, SAH; Ramadan, A; El Hotaby, Walid; Bakeer, Rofanda M
    Acute paracetamol over dose-induced hepatotoxicity is considered an important medical hazard especially among women. Omega-3 long-chain polyunsaturated fatty acids (Omega-3 PUFAs) daily doses are nowadays recommended for their antioxidant and anti-inflammatory potentials. Fourier transform infrared (FTIR) spec- troscopy is considered a reliable method in analyzing cellular alterations and is now efficiently used to diagnose several diseases and the efficacy of drugs even in the early stages. The aim of our study was to evaluate the hepatoprotective effect of Omega-3 PUFAs against paracetamol-induced hepatotoxicity in rats confirmed through measuring protein alterations in hepatocytes by FTIR. Rats were pretreated with Omega-3 PUFAs (50 and 100 mg/kg) for 21 days prior to oral ingestion of paracetamol. FTIR results revealed that Omega-3 PUFAs (50 mg/kg) limited the toxic effects of paracetamol by restoring the hepatic amide I to amide II ratio. In addition; biochemical analyses demonstrated that serum ALT, AST, Cholesterol, LDL-cholesterol and Il-6 levels as well as hepatic TNF-a, MDA, NOx levels were decreased. Besides; serum HDL-cholesterol level and hepatic GSH level were increased. Histopathological examinations of hepatic sections validated the hepatoprotective potential. The overall effect of this dose was comparable to those of the usual recommended hepatoprotective supplement; silymarin. In conclusion; it would be recommended to use Omega-3 PUFAs in low doses on daily bases as a hepatoprotective agent.