Browsing by Author "Dalia Mohamed"

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    A cutting edge potentiometric determination of baricitinib in synthetic wastewater and in tablet dosage form using modified carbon paste ion-selective membrane
    (Elsevier Inc., 2024-09-21) Heba T. Elbalkiny; Mona S. Elshahed; Dalia Mohamed; Azza A. Ashour; Rasha Th. El-Eryan
    After the recent hit of COVID-19, many drugs were successively administered to save patients’ lives and those drugs reached aquatic sources, one of those drugs was Baricitinib. Driven by the current situation, a potentiometric technique using an ion-selective membrane (ISM) recipe drop cast on a modified carbon paste electrode was optimized for the superior determination of Baricitinib (BAR). The molecular docking was customized to optimize the proper ionophores incorporated in the ISM, revealing that beta-cyclodextrin (β-CD) is the most compatible ionophore with the studied drug. A multivariate optimization experimental design was employed to optimize the best experimental condition for the analytical method. To this end; dual nanoparticles (multi-walled carbon nanotubes and copper oxide nanoparticles) were incorporated in the carbon paste electrode, and the ISM recipe was enriched with β-CD and cation-exchanger (phosphotungstic acid) in a polyvinylchloride matrix plasticized with dibutyl phthalate. A Nernstian slope equal to 19.97 mV/decade with a linearity range of 7.99 × 10−7–1.00 × 10−3 M was obtained. The validated sensor exhibited good recovery when used to determine the studied drug in synthetic wastewater and tablet dosage form. The greenness of the method was evaluated using the Complementary Green Analytical Procedure Index and Blue Applicability Grade Index.
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    Eco-friendly tea waste magnetite nanoparticles for enhanced adsorptive removal of norfloxacin and paroxetine from water
    (Elsevier Inc., 2024-11-01) Lamis M. Fahmy; Dalia Mohamed; Marianne Nebsen; Ahmed H. Nadim
    Traces of pharmaceuticals have been detected in water cycle raising concerns regarding the potential risks to human health and aquatic environment. Accordingly, removal of such compounds from water samples is a major concern. Herein, a facile and green NaOH modified tea waste magnetite nanoparticles have been fabricated for the adsorptive removal of a commonly used antibiotic (norfloxacin) and antidepressant (paroxetine) from water samples. The synthesized nanoparticles were characterized using TEM, FT-IR, DLS and VSM. Factors affecting the adsorption efficiency have been investigated with respect to pH (5, 7 and 9), adsorbent amount (0.125, 0.25 and 0.5 g), initial drug concentration (25, 50 and 100 µg/mL) and contact time (0.5, 1 and 2 h). The adsorption isotherms have been calculated. A percentage removal of 98 % and 99 % were obtained for simultaneous removal of 50 µg/mL norfloxacin and paroxetine, respectively in 2 h. Monitoring norfloxacin and paroxetine concentrations was performed through a validated HPLC-DAD method. The reusability of the nanoparticles has been studied for 3 adsorption–desorption cycles. No significant loss in adsorption efficiency was observed offering a sustainable water treatment. This study would offer a facile, green and economic protocol for the removal of complex organic compounds from water resources.