Browsing by Author "C Abbou, Claude"

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    Gefitinib Inhibits the Growth and Invasion of Urothelial Carcinoma Cell Lines in which Akt and MAPK Activation Is Dependent on Constitutive Epidermal Growth Factor Receptor Activation
    (American Association for Cancer Research, 2006) Nicolle, Gaëlle; Daher, Ahmed; Maillé, Pascale; Vermey, Marcel; Loric, Sylvain; Bakkar, Ashraf; Wallerand, Hervé; Vordos, Dimitrios; Vacherot, Francis; Gil Diez De Medina, Sixtina; C Abbou, Claude; Van der Kwast, Theodore; Thiery, Jean-Paul; Radvanyi, François; K Chopin, Dominique
    Abnormally high levels of epidermal growth factor receptor (EGFR) protein are associated with advanced tumor stage/grade. The objective of this study was to evaluate the effects of the specific EGFR tyrosine kinase inhibitor gefitinib on activation of the Akt and mitogen-activated protein kinase (MAPK) pathways in human urothelial cell carcinoma (UCC) cell lines and to identify potential markers of gefitinib responsiveness in biopsy samples of UCC.
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    Occupational exposure to polycyclic aromatic hydrocarbons influenced neither the frequency nor the spectrum of FGFR3 mutations in bladder urothelial carcinoma
    (Wiley Subscription Services, Inc., A Wiley Company, 2010) A Bakkar, Ashraf; Allory, Yves; Iwatsubo, Yuriko; Gil Diez De Medina, Sixtina; Maille, Pascale; Khreich, Nathalie; Riou, Audrey; Leroy, Karen; Vordos, Dimitrios; C Abbou, Claude; Andujar, Pascale; Billebaud, Thierry; Chammings, Soizick; Conso, Françoise; De La Taille, Alexandre; Fontaine, Eric; Gattegno, Bernard; Ravery, Vincent; Sibony, Mathilde; Radvanyi, François; K Chopin, Dominique; Pairon, Jean‐Claude
    Occupational exposure to polycyclic aromatic hydrocarbons (PAH) is associated with an increased risk of urothelial carcinoma (UC). FGFR3 is found mutated in about 70% of Ta tumors, which represent the major group at diagnosis. The influence of PAH on FGFR3 mutations and whether it is related to the emergence or shaping of these mutations is not yet known. We investigated the influence of occupational PAH on the frequency and spectrum of FGFR3 mutations. We included on 170 primary urothelial tumors from five hospitals from France. Patients (median age, 64 yr) were interviewed to gather data on occupational exposure to PAH, revealing 104 non‐ and possibly PAH exposed patients, 66 probably and definitely exposed patients. Tumors were classified as follows: 75 pTa, 52 pT1, and 43 ≥pT2. Tumor grades were as follows: 6 low malignant potential neoplasms (LMPN) and 41 low‐grade and 123 high‐grade carcinomas. The SnaPshot method was used to screen for the following FGFR3 mutations: R248C, S249C, G372C, Y375C, A393E, K652E, K652Q, K652M, and K652T. Occupational PAH exposure was not associated with a particular stage or grade of tumors. Thirty‐nine percent of the tumors harbored FGFR3 mutations. After adjustment for smoking, occupational exposure to PAH did not influence the frequency [OR, 1.10; 95% CI, 0.78–1.52], or spectrum of FGFR3 mutations. Occupational exposure to PAH influenced neither the frequency nor the spectrum of FGFR3 mutations and there was no direct relationship between these mutations and this occupational hazard