Browsing by Author "Bouillaud, Frederic"

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    From electrons to cancer : Redox shift as a driving force of tumorigenesis
    (Elsevier, 2023-11) Attal, Romain; Bakkar, Ashraf; Bouillaud, Frederic; Devin, Anne; Henry, Marc; Ponti´e, Maxime; Radman, Miroslav; Schwartz, Laurent
    Cancer cells are very diverse but mostly share a common metabolic property: they are strongly glycolytic even though oxygen is available. Herein, the metabolic abnormalities of cancer cells are interpreted as modifications of the electric currents in redox reactions. A lower current in the electron transport chain, an increase of the concentration of reduced cofactors and a partial reversal of the tricarboxylic acid cycle are physical characteristics of several forms of cancer. The existence of electric short-circuits between oxidative branches and reductive branches of the metabolic network argue in favor of an electronic approach of cancer in the nanoscopic scale. These changes of electron flows induce a pseudo-hypoxia and the Warburg effect through succinate production and divert electrons from oxygen to biosynthetic pathways. This new look at cancer may have potential therapeutic applications.