Browsing by Author "Attia A.K."

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    Electrochemical determination of tolfenamic acid in bulk, tablets and urine
    (Center of Excellence in Electrochemistry, Univ. of Tehran, 2017) Attia A.K.; Rashed N.S.; Fouad M.M.; Wasfy R.A.; National Organization for Drug Control and Research (NODCAR); Cairo; Egypt; Analytical Chemistry Department; Faculty of Pharmacy; Al-Azhar University; Cairo; Egypt; October University for Modern Sciences and Arts (MSA); Cairo; Egypt
    A simple, precise, accurate and inexpensive voltammetric method was developed for the quantitative determination of tolfenamic acid at modified glassy carbon electrode in phosphate buffer of pH 7.2. Several factors such as type of buffer, type of surfactant; scan rate and accumulation time were studied to obtain the optimum conditions for the determination of tolfenamic acid. The proposed method shows linearity in concentration range of 6.0. 10-7-6.0. 10-6 mol L-1 with mean percentage recovery of 101.2. 1.99. The limits of detection and quantification were 1.43. 10-7 mol L-1 and 4.34. 10-7 mol L-1, respectively. The proposed voltammetric method was successfully applied to determine tolfenamic acid in pharmaceutical formulations and human urine. The results of the proposed method were statistically compared with those of a reported method and showed no significant difference. Thus, it can be used as quality control for this drug in laboratories.. 2017 by CEE (Center of Excellence in Electrochemistry).
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    Simultaneous determination of ramipril and felodipine using carbon paste electrode in micellar medium
    (Center of Excellence in Electrochemistry, Univ. of Tehran, 2019) Taha E.A.; Attia A.K.; Fouad M.M.; Yousef Z.M.; National Organization for Drug Control and Research (NODCAR); Giza; Egypt; Analytical Chemistry Department; Faculty of Pharmacy Al-Azhar University; Cairo Egypt and October University for Modern Sciences and Arts; Egypt
    Simple, precise, inexpensive and sensitive voltammetric method was developed for simultaneous determination of Ramipril (RAM) and felodipine (FLD) mixture in drug substance, drug product and human urine using carbon paste electrode (CPE). Effect of different surfactants on peak current was studied in acetate buffer solution of pH 4.8. Sodium dodecyl sulphate (SDS) is the optimum surfactant based on the enhancement of the peak current. The peak current varied linearly over the concentration ranges from 5�10-5 mol L-1 to 8�10-4 mol L-1 for both drugs. The quantification limits were 1.78�10-5 and 1.94�10-5 mol L-1 and detections limits were 4.5�10-6 and 2.7�10-6 mol L-1 for RAM and FLD, respectively. The proposed voltammetric method was successfully applied to determine RAM and FLD mixture in drug product and human urine. The results of the proposed method were statistically compared with those of the reported method and showed no significant difference. Thus, it can be applied for quality control of both drugs. � 2019 by CEE (Center of Excellence in Electrochemistry).