Browsing by Author "Attia, KA"

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Different spectrophotometric methods applied for the analysis of binary mixture of flucloxacillin and amoxicillin: A comparative study
(PERGAMON-ELSEVIER SCIENCE LTD, 5/15/2016) Serag, A; El-Zeiny, MB; Nassar, MW; Attia, KA
Three different spectrophotometric methods were applied for the quantitative analysis of flucloxacillin and amoxicillin in their binary mixture, namely, ratio subtraction, absorbance subtraction and amplitude modulation. A comparative study was done listing the advantages and the disadvantages of each method. All the methods were validated according to the ICH guidelines and the obtained accuracy, precision and repeatability were found to be within the acceptable limits. The selectivity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. So, they can be used for the routine analysis of flucloxacillin and amoxicillin in their binary mixtures. (C) 2016 Elsevier B.V. All rights reserved.
Firefly algorithm versus genetic algorithm as powerful variable selection tools and their effect on different multivariate calibration models in spectroscopy: A comparative study
(PERGAMON-ELSEVIER SCIENCE LTD, 01/05/2017) Serag, A; El-Zeiny, MB; Nassar, MW; Attia, KA
For the first time, a new variable selection method based on swarm intelligence namely firefly algorithm is coupled with three different multivariate calibration models namely, concentration residual augmented classical least squares, artificial neural network and support vector regression in UV spectral data. A comparative study between the firefly algorithm and the well-known genetic algorithm was developed. The discussion revealed the superiority of using this new powerful algorithm over the well-known genetic algorithm. Moreover, different statistical tests were performed and no significant differences were found between all the models regarding their predictabilities. This ensures that simpler and faster models were obtained without any deterioration of the quality of the calibration. (C) 2016 Elsevier B.V. All rights reserved.
Stability-indicating methods for the analysis of ciprofloxacin in the presence of its acid induced degradation product: A comparative study
(PERGAMON-ELSEVIER SCIENCE LTD, 4/15/2016) Serag, A; El-Zeiny, MB; Nassar, MW; Attia, KA
Four rapid, simple, accurate and precise spectrophotometric methods were used for the determination of ciprofloxacin in the presence of its acidic degradation product. The methods under study are ratio derivative, ratio difference, mean centering and dual wavelength. All the methods were validated according to the ICH guidelines and the obtained accuracy, precision and repeatability were found to be within the acceptable limits. The selectivity of the proposed methods was tested using laboratory prepared mixtures and assessed by applying the standard addition technique. So, they can be used for the routine analysis of ciprofloxacin in quality-control laboratories. (C) 2016 Elsevier B.V. All rights reserved.