Browsing by Author "Attar A.M."

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Recent Updates in Pharmacological Properties of Chitooligosaccharides
    (Hindawi Limited, 2019) Marmouzi I.; Ezzat, Shahira M; Salama M.M.; Merghany R.M.; Attar A.M.; El-Desoky A.M.; Mohamed S.O.; University Mohammed v in Rabat; Facult� de M�dicine et Pharmacie; Laboratoire de Pharmacologie et Toxicologie; �quipe de Pharmacocin�tique; Rabat; Morocco; Pharmacognosy Department; Faculty of Pharmacy; Cairo University; Kasr El-Ainy Street; Cairo; 11562; Egypt; Department of Pharmacognosy; Faculty of Pharmacy; October University for Modern Sciences and Arts (MSA); 6th October12611; Egypt; Department of Pharmacognosy and Medicinal Plants; Faculty of Pharmacy; British University in Egypt; Cairo; 11837; Egypt; Department of Pharmacognosy; National Research Centre; Giza; Egypt; Faculty of Science and Techniques; Hassan II University of Casablanca; Mohammedia; Morocco; Department of Molecular Biology; Genetic Engineering and Biotechnology Research Institute (GEBRI); University of Sadat City (USC); Sadat City; Egypt; Natural Wellness Scientific Office; Kuala Lumpur; Malaysia
    Chemical structures derived from marine foods are highly diverse and pharmacologically promising. In particular, chitooligosaccharides (COS) present a safe pharmacokinetic profile and a great source of new bioactive polymers. This review describes the antioxidant, anti-inflammatory, and antidiabetic properties of COS from recent publications. Thus, COS constitute an effective agent against oxidative stress, cellular damage, and inflammatory pathogenesis. The mechanisms of action and targeted therapeutic pathways of COS are summarized and discussed. COS may act as antioxidants via their radical scavenging activity and by decreasing oxidative stress markers. The mechanism of COS antidiabetic effect is characterized by an acceleration of pancreatic islets proliferation, an increase in insulin secretion and sensitivity, a reduction of postprandial glucose, and an improvement of glucose uptake. COS upregulate the GLUT2 and inhibit digestive enzyme and glucose transporters. Furthermore, they resulted in reduction of gluconeogenesis and promotion of glucose conversion. On the other hand, the COS decrease inflammatory mediators, suppress the activation of NF-B, increase the phosphorylation of kinase, and stimulate the proliferation of lymphocytes. Overall, this review brings evidence from experimental data about protective effect of COS. � 2019 Ilias Marmouzi et al.