Browsing by Author "Ammar H.O."

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    Enhancement of oral bioavailability of repaglinide by self-nanoemulsifying drug delivery system
    (International Journal of Pharmacy and Pharmaceutical Science, 2014) Ammar H.O.; El-Fek G.S.; Abdelhaleem Ali A.M.; Dawood R.A.G.; Department of Pharmaceutical Technology; Future University in Egypt and Department of Pharmaceutical Technology; National Research Center; Egypt; Department of Pharmaceutics; October University for Modern Sciences and Arts and Department of Pharmaceutical Technology; National Research Center; Egypt; Department of Pharmaceutics; BeniSuef University; Egypt
    Repaglinide is considered the drug of choice for diabetic patients with impaired kidney function as it is excreted mainly in the bile. Unfortunately, it possesses low oral bioavailability of approximately 56%. Therefore, nano-sized globules containing the drug are expected to enhance its bioavailability and sustain its glucose lowering action. Self nano-emulsifying drug delivery systems (SNEDDS) of repaglinide have been prepared for improving the water solubility and oral bioavailability of the drug. Various compositions of SNEDDS were prepared using four types of oils (oleic acid, isopropyl myristate IPM. Labrafil 1944 and 2125), surfactants (chromophore El35, chromophore RH 40, Labrasol and Span 20) and a variety of co-surfacatnts. Low energy emulsification was adopted as the method of preparation for its feasibility and low cost. The prepared nano-emulsions showed small average droplet size (13.5-20 nm) and low polydispersity index (0.10 - 0.30). In-vitro dissolution studies indicated that the drug release from some of the prepared nanoemulsion droplets reached 75% within the first 30 minutes. The in-vivo data demonstrated that repaglinide in the nano-emulsion formulations F8 (IPM, Cremophor EL35 and Propylene glycol) and F16 (Oleic acid, Cremophor RH40 and Lauroglycol FCC) lowered the plasma glucose level (< 110 mg/dL) of experimental rabbits in a similar trend to that of the commercial product (Novonorm 2014, International Journal of Pharmacy and Pharmaceutical Sciences. All rights reserved.
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    Topical liquid crystalline gel containing lornoxicam/cyclodextrin complex
    (2012) Ammar H.O.; Ghorab M.; Mahmoud A.A.; Makram T.S.; Noshi S.H.; Department of Pharmaceutical Technology; National Research Center; Tahreer St.; Dokki; Cairo; Egypt; Department of Pharmaceutics; Faculty of Pharmacy; Cairo University; Cairo; Egypt; Department of Pharmaceutics; Faculty of Pharmacy; October 6th University; Cairo; Egypt; Department of Pharmaceutics; Faculty of Pharmacy; MSA University; Cairo; Egypt
    Lornoxicam is a potent analgesic non-steroidal anti-inflammatory drug that can be used topically to relieve pain and to reduce inflammation. The objectives of this study were to improve the therapeutic efficacy of lornoxicam by complexation with cyclodextrins and to formulate it in liquid crystalline gel. Lornoxicam and ?-cyclodextrin (?CD) or hydroxypropyl-?- cyclodextrin (HP?CD) complexes were prepared using the kneaded method in 1:1, 1:2, 1:3 and 1:4 drug:CD molar ratios. Inclusion complexation in aqueous solution and solid state was evaluated by the ultraviolet, phase solubility diagram, differential scanning calorimetry, X-ray diffractometry and Fourier-transform infrared spectroscopy. The stoichiometry for the inclusion complex was found to be 1:2 drug:CD molar ratio as determined from Job's plot. This result was confirmed by the in vitro dissolution studies for the prepared complexes. Among all the prepared complexes, the complex prepared with ?CD in 1:2 drug:CD molar ratio showed highest improvement in drug dissolution and was chosen to be formulated in a topical preparation. For developing liquid crystalline gel, different ratios of Brij 97, glycerol and oils (liquid paraffin, isopropyl myristate and Miglyol � 812) were prepared. The formula composed of Brij 97 and glycerol in 3:1 weight ratio, 10% Miglyol � 812 and 40% water showed higher drug release compared to the other prepared gels. Moreover, this formula showed low ex vivo permeation on excised pigskin thus it could offer high topical effect with low systematic side effects. This formula showed superior anti-inflammatory activity when applied topically on rats' skin after induction of burn compared to that of Feldene � gel. � 2011 Springer Science+Business Media B.V.