Browsing by Author "Amer S.M."

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    Ion selective membrane electrodes for determination of Citalopram Hydrobromide in drug product and in presence of its degradation products
    (Center of Excellence in Electrochemistry, Univ. of Tehran, 2015) Nebsen M.; El-Maraghy C.M.; Salem H.; Amer S.M.; Analytical Chemistry department; Cairo University; Kasr-El Aini Street; Cairo; 11562; Egypt; Pharmaceutical Analytical Chemistry department; Heliopolis University; 3 Cairo Belbeis desert road; El-Horria; Cairo; 2834; Egypt; Analytical Chemistry department; October University for Modern Sciences and Arts (MSA); 6th October city; 11787; Egypt; Pharmaceutical Analytical Chemistry department; Deraya University; Minia; Egypt
    This paper presents a comparative study between three sensors developed to determine Citalopram Hydrobromide (CT) in the presence of its alkaline hydrolysis and oxidation induced degradation products using different ion association complexes. Sensor 1 was fabricated using phosphomolybdic acid, Sensor 2 used phosphotungestic acid and sensor 3 used the sodium tetraphenyl borate. Linear responses of CT were obtained within the concentration ranges of 1�10?6 to 1�10?2 mol L-1 for sensor 1 and 2 and 1�10?5 to 1�10?2 mol L-1 for sensor 3 over the pH range of 3.0�6.0. The selectivity coefficients of the developed sensors indicated excellent selectivity for CT. The proposed sensors displayed useful analytical characteristics for the determination of CT in bulk powder, pharmaceutical formulation, and in the presence of its degradation products and thus could be used for stability-indicating methods. The method was validated according to ICH guidelines. Statistical comparison between the results from the proposed method and the results from the reference HPLC method showed no significant difference regarding accuracy and precision. � 2015 by CEE (Center of Excellence in Electrochemistry).
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    Novel membrane sensors for the determination of quetiapine fumarate in plasma and in presence of its related compounds
    (Center of Excellence in Electrochemistry, Univ. of Tehran, 2016) Nebsen M.; El-Maraghy C.M.; Salem H.; Amer S.M.; Cairo University; Analytical Chemistry department; Kasr-El Aini Street; Cairo; 11562; Egypt; Pharmaceutical Analytical Chemistry department; Drug Technology; Heliopolis University; 3 Cairo Belbeis desert road; Horria; Cairo; 2834El; Egypt; Analytical Chemistry department; October University for Modern Sciences and Arts(MSA); 6th October city; 11787; Egypt; Pharmaceutical Analytical Chemistry department; Deraya University; Minia; Egypt
    Two sensitive and selective polyvinyl chloride (PVC) matrix membrane sensors were developed and investigated for determination of the cationic drug Quetiapine Fumarate (QTF) in pure form, in plasma and in presence of its two related compounds namely Quetiapine N-oxide and Des-ethanol Quetiapine. The two sensors (? and ??) were developed using sodium tetraphenyl borate as a cation exchanger with dioctyl phthalate (DOP) as a plasticizer. Selective molecular recognition component, ?-cyclodextrin (?-CD), was used as ionophore to improve the selectivity of sensor II. The proposed sensors had a linear dynamic range of 1�10-6 -1�10-2 mol L-1 for sensor ? and 1�10-7 -1�10-2 mol L-1 for sensor ?? with Nernstian slopes of 27.50�0.45 and 39.85�0.3 mV/decade for sensors I and II, respectively over the pH ranges of 2.5-7. The method was validated according to ICH guidelines. Statistical comparison between the results from the proposed method and the results from the reference HPLC method showed no significant difference regarding the accuracy and precision. � 2016, Center of Excellence in Electrochemistry, Univ. of Tehran. All rights reserved.