Browsing by Author "Ali, Rania S"

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Synthesis of New Benzoxazinone, Quinazolinone, and Pyrazoloquinazolinone Derivatives and Evaluation of Their Cytotoxic Activity Against Human Breast Cancer Cells
(WILEY, 111 RIVER ST, 2018-05) El‐Bordany, Eman A.; Ali, Rania S
Synthesis of 2-[3-(3,4-dichlorophenyl)-3-oxoprop-1-enyl]-4H-benzo[3,1]oxazin-4-one 2 as a precursor to synthesize quinazolinones 5, 7 pyrazolylquinazolinones, 4, 12, 13, 14, 16 benzothiazine thione 10, benzene derivative 3 pyrroloquinazolinone 6, benzoimidazoquinazolinone 8, and pyrazolotriazepinoquinazolinone 15. The structures of the newly synthesized compounds were established by their elemental analyses and spectral data. Most of the synthesized compounds exhibited high antitumor and cytotoxic activity against human breast cancer cells.