Browsing by Author "Albalawi, Marzough Aziz"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    The medicinal activity of lyophilized aqueous seed extract of Lepidium sativum L. in an androgenic alopecia model
    (Nature Publishing Group, 2023-05) Albalawi, Marzough Aziz; Hafez, Ahmed M; Elhawary, Seham S; Sedky, Nada K; Hassan, Omnia F; Bakeer, Rofanda M; Abd El Hadi, Soha; El‑Desoky, Ahmed H; Mahgoub, Sebaey; Mokhtar, Fatma A
    This study evaluated the topical efect of Lepidium sativum lyophilized seed extract (LSLE) towards Sustanon-induced alopecia in male adult Wistar albino rats in vivo, compared to minoxidil topical reference standard drug (MRD). LC–MS/MS together with molecular networking was used to profle the metabolites of LSLE. LSLE treated group revealed signifcant changes in alopecia related biomarkers, perturbation of androgenic markers; decline in testosterone level and elevation in 5α-reductase (5-AR); decline in the cholesterol level. On the other hand, LSLE treated group showed improvement in vascular markers; CTGF, FGF and VEGF. Groups treated topically with minoxidil and LSLE showed signifcant improvement in hair length. LC–MS/MS profle of LSLE tentatively identifed 17 constituents: mainly glucosinolates, favonoid glycosides, alkaloids and phenolic acids. The results point to the potential role of LSLE in the treatment of alopecia through decreasing 5(alpha)- dihydrotestosterone levels. Molecular docking was attempted to evaluate the probable binding mode of identifed compounds to androgen receptor (PDB code: 4K7A).