Browsing by Author "Al Shawoush, Abdeljalil Mohamed"

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    Biointerfrence between Zinc Oxide/Alginate Nanocomposites and Freshwater Bivalve
    (AMG Transcend Association, 2022-07) Omar, Tahani Younis; Elshenawy, Habiba Ihab Ahmed; Abdelfattah, Marwa Ahmed; Al Shawoush, Abdeljalil Mohamed; Mohamed, Ayman Saber; Saad, Dalia Y
    Commercial usage of zinc oxide nanoparticles threatens the aquatic ecosystem. The green synthesis of ZnO nanoparticles is an environmentally benign method of nanoparticle manufacture. Aim: In the current study, freshwater bivalves were employed as a crucial indicator for the green synthesis of alginate/ZnO nanocomposite. Transmission electron microscopy, ultraviolet spectroscopy, and X-Ray diffraction were used to analyze the produced Alginate/ZnO nanocomposite. The bivalve was subjected to various dosages of ZnO and alginate/ZnO nanoparticles (12, 25, and 50 mg/L). The alginate/ZnO nanocomposite size was between (10-15 nm), whereas ZnO was between (5-10 nm). Malondialdehyde and nitric oxide levels increased at all Alginate/ZnO nanocomposite doses, whereas catalase and glutathione levels decreased in all organs. After exposure to alginate/ZnO nanocomposite nanoparticles, the gills and mantle histopathological examinations revealed changes. Incorporating alginate into the production of ZnONPs causes combinatorial harmful effects in Coelatora aegyptica, including oxidative stress and histopathological alterations. Coelatora aegyptiaca was found to be a sensitive bio- indicator for nanoparticle-induced water pollution.
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    Therapeutic potency of gallium verum extract on ethanol-induced gastric ulcer in rats
    (AMG Transcend Association, 15/10/2022) Lotfy, Bassant Mohamed Mohamed; Mousa, Mohamed R; El-Shehry, Mona Samir Fawzy El-Sayed; Ahmed, Salma Hussein Abdel-Fattah; Ali, Sara Bayoumi; Al Shawoush, Abdeljalil Mohamed; Mohamed, Ayman Saber
    Gallium verum, lady's bedstraw is an herbaceous annual plant belonging to the genus Rubiaceae; it possessed antioxidant, cytotoxic for cancer cells, antimicrobial, protective and endocrine effects. This work aimed to investigate the curative effects of G. verum extract on gastric ulcers following absolute ethanol administration in the healthy rat. Eighteen rats were randomly divided into three main groups; rats were fastened for 24 hours before ethanol administration. All groups except control administered ethanol (5 ml/kg body weight; orally). The rats were administrated distilled water (Ulcer group) or G. verum extract (100mg/kg) one hour later. G. verum extract caused a significant decrease in ulcer index, gastric juice volume, malondialdehyde, and nitric oxide, while gastric juice pH, glutathione, glutathione-S-transferase, and catalase increased significantly. The histological lesion score showed a significant enhancement in group G. verum compared to the ulcer group that scored the highest pathological destruction score. Immunohistochemical markers of NF-κB p65 and TNF-α showed a significant decrease in G. verum group. G. verum extract is a promising treatment modality against gastric injury through its powerful antioxidant, acid neutralizing, healing promotion, and ant- inflammation effects.