Browsing by Author "Abo Nahas, Hebatallah H"

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Biodiversity and Industrial Applications of Genus Chaetomium
(Springer, 6/19/2021) Abdel-Azeem, Ahmed M; Abu-Elsaoud, Abdelghafar M; Abo Nahas, Hebatallah H; Abdel-Azeem, Mohamed A; Balbool, Bassem A; Mousa, Mariam K; Ali, Nehal H; Darwish, Amira M. G
When Gustav Kunze introduced genus Chaetomium, as a new genus to the science, in Mykologische Hefte (Leipzig) in 1817, the new taxon attracted the interest of the researchers in every place in the world. Genus Chaetomium is a very diverse taxon colonizing various substrates rich in cellulose such as soils, textiles, plant tissues, agricultural wastes, and seeds. The genus Chaetomium is considered one of the largest genera in saprobic ascomycetes, which belongs to order Sordariales and family Chaetomiaceae. Until now more than 500 compounds with a wide range of bioactive effects have been isolated from Chaetomium spp., but compared with its richness of species, more bioactive secondary metabolites might be found in this member of fungi. Therefore, together with its ubiquitous nature, these species have great significant impacts on ecosystems, agriculture, food production, biotechnology, and human and animal health. The goal of this chapter is to shed the light on the biodiversity of Chaetomium in different ecological habitats with its application in different industrial fields.
A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19
(MDPI, 21/10/2021) Saied, Essa M; El-Maradny, Yousra A; Osman, Alaa A; Darwish, Amira M. G; Abo Nahas, Hebatallah H; Niedbała, Gniewko; Piekutowska, Magdalena; Abdel-Rahman, Mohamed A; Balbool, Bassem A; Abdel-Azeem, Ahmed M
In 2019, the world suffered from the emergence of COVID-19 infection, one of the most difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have been reported worldwide. This disaster was caused by SARS-CoV-2, which is the last discovered member of the family of Coronaviridae. Various studies have shown that natural compounds have effective antiviral properties against coronaviruses by inhibiting multiple viral targets, including spike proteins and viral enzymes. This review presents the classification and a detailed explanation of the SARS- CoV-2 molecular characteristics and structure–function relationships. We present all currently available crystal structures of different SARS-CoV-2 proteins and emphasized on the crystal structure of different virus proteins and the binding modes of their ligands. This review also discusses the various therapeutic approaches for COVID-19 treatment and available vaccinations. In addition, we highlight and compare the existing data about natural compounds extracted from algae, fungi, plants, and scorpion venom that were used as antiviral agents against SARS-CoV-2 infection. Moreover, we discuss the repurposing of select approved therapeutic agents that have been used in the treatment of other viruses.