Browsing by Author "Abdel-Nasser, Zeinab M"

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    Modulation of the miR-122/Sirt-6/ACE2 axis on experimentally-induced myocardial infarction
    (Elsevier Ireland Ltd, 2022-11) Abdel-Nasser, Zeinab M; Zaafan, Mai A; Abdelhamid, Amr M
    Myocardial infarction (MI) is a progressive myocardial necrosis that can lead to a number of life- threatening complications. MiRNAs have a crucial role in the pathogenesis of many cardiovascular diseases. Remarkably, miR-122 targets the sirtuin-6 (Sirt-6) gene, which is an essential regulator of cardiovascular function and is considered a partial angiotensin converting enzyme 2 (ACE2) activator. Modulation of this axis is supposed to contribute to MI pathogenesis. The current study aims to investigate the cardioprotective effects of xanthenone through targeting the miR-122/Sirt-6/ACE2 axis on experimentally-induced MI in rats. Xanthenone was administered for 14 days and isoprenaline was injected in the last 2 days of the experiment. Xanthenone treatment resulted in a significant downregulation of miR-122, which further upregulated Sirt-6 and thus activated the adenosine monophosphate-activated protein kinase (AMPK). AMPK increases ACE2 levels and results in a decrease in the level of its substrate angiotensin II resulting in the normalization of the inflammatory cytokines and the cardiac biomarkers. Finally, by targeting the miR-122/Sirt-6/AMPK/ACE2 axis, xanthenone has the potential to be a promising cardioprotective agent against MI.
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    Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs: Evolutionary perspective in managing pulmonary fibrosis
    (Elsevier Masson s.r.l., 2022-07-27) El-Kashef, Dalia H; Youssef, Mahmoud E; Nasr, Mohamed; Alrouji, Mohammed; Alhajlah, Sharif; AlOmeirf, Othman; El Adle Khalaf, Noura; Abdel Ghaffar, Dalia M; Jamil, Lubna; Abdel-Nasser, Zeinab M; Ibrahim, Samar; Abdeldaiem, Mahmoud Said Ibrahim; Donia, Sally S; Mohammed, Osama A; Morsy, Nesreen Elsayed; Shata, Ahmed; Saber, Sameh
    Idiopathic pulmonary fibrosis is a fatal lung disorder in which the etiology and pathogenesis are still unobvious. Effective treatments are urgently needed considering that lung transplantation is the only treatment that could improve outcomes. This study aimed to investigate the therapeutic significance of the dual administration of pimitespib, an HSP90 inhibitor, and nifuroxazide, a STAT3 inhibitor, against bleomycin-induced pulmonary