Browsing by Author "Abd Elaty Mostafa, Dalia"

Now showing 1 - 3 of 3

Comparison Between the Pharmacokinetics Data of Ketorolac Tromethamine Wafer a Novel Drug Delivery System and Conventional Ketorolac Tromethamine Tablets to Enhance Patient Compliance Using a New LC-MS/MS Method
(Springer, 3/26/2020) Abd Elaty Mostafa, Dalia; Mostafa Hashad, Amira; Ragab, Mai F.; Wagdy, Hebatallah A
potent and widely used non-steroidal anti-inflammatory drug. Despite its efficacy, it causes gastric irritation and increases the risk of gastrointestinal injuries. This study aimed to formulate KTM wafer to overcome its harmful gastrointestinal side effects. By solvent evaporation method six formulae prepared with different concentrations of polymers of sodium carboxymethyl cellulose, sodium alginate, and hydroxypropyl methylcellulose (HPMC E15). The formula F2 with high concentration of sodium alginate wafer, shows disintegration time in 85 s, with pH 6.6,% drug loaded with 102% and high dissolution release rate in 20 min. Drug release pattern appears to be second order. The mean Cpmax values of F2 wafer and the marketed product were 2135.47 ± 13.83 ng/mL and 1073 ± 23.5, respectively. The median values of Tmax were 1 and 3 h, respectively. The calculated AUC0 − ∞values were 2087 ± 71.58 and 3981 ± 62.34 ng h/mL for F2 and marketed product, correspondingly. The relative bioavailability was found to be 0.52. A new rapid, sensitive, and specific LC-MS/MS fully validated method was developed for the determination and quantification of KTM, using torsemide as internal standard, in biological sample. It was successfully applied to perform the pharmacokinetic and the bioavailability study. © 2020, Springer Science+Business Media, LLC, part of Springer Nature
A Novel Vesicular Lipid Carrier Systems to Enhance Acyclovir Delivery through Skin
(International Journal of Pharmaceutical Research & Allied Sciences, 2018) Abd Elaty Mostafa, Dalia; Mostafa Hashad, Amira; Youssef M. Abdelreheem, Amal
There has always been a growing need for novel drug delivery systems to deal with chemical drug entities that have poor solubility and permeability. A great deal of interest has been being focused on the utilization of lipid based drug delivery systems such as ethosomes to enhance the permeation of antiviral drugs through the skin. Ethosomes have been employed to improve the permeability of drugs through different mechanisms. Acyclovir can pass easily through the skin to reach deep dermis layer where the virus replicates thus, enhancing the overall effect of the drug. Ethosomes comprise of various types of phospholipid structures, water, and low molecular weight alcohol (ethanol or isopropyl alcohol) in high concentration that provide malleability to the vesicle membrane. Hence, ethosomes loaded of Acyclovir were prepared with a purpose of overcoming these drawbacks. Ethosomes loaded sustained release formulations of Acyclovir were prepared using the hot method technique. The proposed formulations of Acyclovir loaded ethosomes were characterized for their morphology, particle size, zeta potential and entrapment efficiency and in vitro release study. The morphology of ethosomes showed ideal particle size and appearance. The entrapment efficiency was between 94.95 % and 98.56%, and the particle size was found between 276.3 nanometers to 677.7 nanometers. The porous structure of ethosomes was confirmed by an optical microscope and a transmission electron microscope. It also showed the highest release profile with nearly 28% release after 8 hours. F1 exhibited a zeta potential score of -67.8 indicating good stability. F1 in-vitro permeation study showed a promising penetration enhancement.
Review on niosomalstructure Through nasal Route
(Journal of Pharmacy and Biological Sciences, 2018) Abd Elaty Mostafa, Dalia; Mostafa Hashad, Amira
Nanotechnology has created one of the most dynamic science and technology domains at the confluence of physical sciences, molecular engineering, biology, biotechnology and medicine. There has been a considerable research interest in the area of developing drug delivery using nanoparticles (NP’s) as carriers for small and large molecules. Targeting delivery of drugs to the diseased lesions is one of the most important aspects of drug delivery system especially brain. They have been used in-vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to this site of action. Niosomes are non-ionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. Various polymers have been used in the formulation of niosomes for drug delivery research to increase therapeutic benefit, while minimizing the side-effects. It is obvious that niosome appears to be a well preferred drug delivery system over liposome as niosome being stable and economic. Also niosomes have great drug delivery potential for targeted delivery of anti-cancer, antiinfective agents.Drug delivery potential of niosome can enhance by using novel concepts like proniosomes, discomes and aspasome.Niosomes represent a promising drug delivery module. Niosomes are thoughts to be better candidates drug delivery as compared to liposomes due to various factors like cost, stability etc. Various types of drug deliveries can be possible using niosomes like targeting, ophthalmic, topical and parenteral.