Browsing by Author "A Elkady, Omar"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Multi-Drug Loaded Chitosan/Gelatin Composite Sponge for Dental Application
    (International Journal of Research in Medical &Applied Sciences, 2015) A Elkady, Omar
    The extraction of impacted third molar teeth can significantly lead to postoperative pain, swelling and trismus which delay hospital discharge. Dexamethasone steroid and Diclofenac are commonly prescribed to prevent inflammatory sequelae and relieve the associated pain. In this study, gelatin/chitosan blend was used for the preparation of dexamethasone-diclofenac sponge to be implanted directly to the socket benefiting from (1) the biodegradable nature of the polymers used as taking out the sponge after treatment always causes new damage to the wound.(2) The interaction between positively charged chitosan and negatively charged gelatin. The conditions expected to affect the stability of gelatin foams were optimized and the sponge was prepared by the lyophilization of stable foams generated by stirring a mixture of 7% aqueous gelatin and 2.5% chitosan in 1% acetic acid in a ratio of 1: 5 respectively at 1000 rpm for 10 minutes. Scanning Electron Microscopy (SEM) was used to elucidate the internal structure of the developed sponge where drug crystals were detected on the lamellae and within pores of the sponge. In general, sponge formulae D, E and F showed higher and fast absorption behaviour reaching up to 2023% of its weight after 15 minutes only