Browsing by Author "A El-Maraghy, Shohda"

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    Antidiabetic activity of phenolic compounds from Pecan bark in streptozotocin-induced diabetic rats
    (Elseiver, 2011) M Abdallah, Hossam; M Salama, Maha; H Abd-Elrahman, Enas; A El-Maraghy, Shohda
    The n-butanol fraction (BF) of bark of Pecan tree, Carya illinoinensis (Wangenh) K. Koch (Juglandaceae) afforded two new flavonol methyl ether: caryatin-3′ sulfate (6) and caryatin-3′ methyl ether-7-O-β-d-glucoside (7) while five known phenolics (1–5) were isolated from its ethyl acetate fraction (EAF). The structures of isolated compounds were established based on 1D and 2D NMR spectroscopy. The isolated compounds were investigated for their hypoglycaemic, antioxidant as well as the aldose reductase (AR) inhibitory effect in lenses of streptozocin diabetic rats. All the isolated compounds showed significant hypoglycaemic and antioxidant activities, except 5 and 6. A marked AR-inhibitory effect was identified for compounds 2, 3 and 7.
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    Hepatoprotective constituents of Torilis radiata Moench (Apiaceae)
    (Taylor & Francis Group, 2012) Ezzat, Shahira M; M Abdallah, Hossam; A Fawzy, Ghada; A El-Maraghy, Shohda
    An investigation of the aqueous ethanolic extract (AE) of the aerial parts of Torilis radiata Moench yielded two triterpenes (lupeol acetate 1 and α-amyrin 2), a sterol (spinasterol 3) from its n-hexane fraction (HF), a flavone (acacetin 4), a coumarin (scopoletin 5), a phenolic acid (ferulic acid 6) from the chloroform fraction (CF) and a flavone glycoside (luteolin-7- O-glucoside 7) from the n-butanol fraction (BF). The hepatoprotection of the AE and its fractions was assessed in terms of the reduction in histological damage, accompanied by restoration of the liver enzymes (alanine amino transferase (ALT), aspartate amino transferase (AST), lactate dehydrogenase (LDH)), a reduction in the inflammatory markers (tumour necrosis-α (TNF-α), nitric oxide (NO), N-acetyl-β-D-glucosaminidase (NAG) and myloperoxidase (MPO) in serum), and a restoration of the oxidant balance through decreasing the serum and hepatic malondialdehyde (MDA) levels, along with increasing the activity of hepatic catalase (CAT), glutathione peroxidase (GSHPx) and the non-enzymatic antioxidant glutathione (GSH).