A comparative study of different aspects in manipulating ratio spectra used for the analysis of cefradine in the presence of its alkaline degradation product
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A comparative study of different aspects in manipulating ratio spectra used for the analysis of cefradine in the presence of its alkaline degradation product
Series Info:SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY;Volume: 207 Pages: 105-111
Type:Article
Keywords:CefradineSpectrophotometry
,
Ratio difference
,
Mean centering
,
Derivative ratio
,
Savitsky-Golay filter
,
Continuous wavelet transform
,
Derivative continuous wavelet transform
,
CHARGE-TRANSFER COMPLEXATION
,
SPECTROPHOTOMETRIC METHOD
,
University for Modern Sciences and Arts
Abstract:
Six stability-indicating UV-spectrophotometric methods manipulating ratio spectra were utilized for the analysis of cefradine in presence of its alkaline degradate. These methods are different forms of transformations; ratio difference, mean centering, derivative ratio using numerical differentiation, derivative ratio using Savitsky-Golay filter, continuous wavelet transform and derivative continuous wavelet transform. Water was used as a solvent and the linearity ranges were 6-26 mu g/mL. Determination of accuracy and precision for the suggested procedures were executed. Assessment of specificity was run through analyzing laboratory prepared mixtures containing cefradine and its alkaline degradate. The suggested methods were useful for cefradine estimation in tablets. Statistically, the outputs obtained from the recommended and published methods reveal no significant differences. (C) 2018 Elsevier B.V. All rights reserved.