dc.contributor.author |
Salman AlMarzouq, Douaa |
|
dc.contributor.author |
M Hilmy Elnagdi, Noha |
|
dc.date.accessioned |
2019-11-06T11:49:52Z |
|
dc.date.available |
2019-11-06T11:49:52Z |
|
dc.date.issued |
2019 |
|
dc.identifier.issn |
1420-3049 |
|
dc.identifier.other |
https://doi.org/10.3390/molecules24091806 |
|
dc.identifier.uri |
https://cutt.ly/deTZGKK |
|
dc.description.abstract |
The role of glycerol as a green bio-based solvent, reactant, and/or a catalyst in the synthesis of novel heterocycles, under pressure, is studied. Synthesis of novel quinolines in good yields using a new modified Skraup synthesis, utilizing glycerol and pressure Q-tubes, is demonstrated. Novel aniline trimers are prepared using glycerol, and substituted anilines under pressure, in acidic medium and water. Glycerol was employed as a catalyst and a green solvent in the synthesis of novel pyridazines 13a-c. The mechanisms of the reactions and the catalytic effect of glycerol in protic and aprotic media are fully discussed. The structures of the synthesized compounds were determined via X-ray crystallography and spectroscopic methods. |
en_US |
dc.description.sponsorship |
MDPI |
en_US |
dc.description.uri |
https://www.scimagojr.com/journalsearch.php?q=26370&tip=sid&clean=0 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
MDPI |
en_US |
dc.relation.ispartofseries |
MOLECULES;Volume: 24 Issue: 9 |
|
dc.relation.uri |
https://cutt.ly/leTvLbG |
|
dc.subject |
glycerol |
en_US |
dc.subject |
green chemistry |
en_US |
dc.subject |
modified Skraup's quinoline synthesis |
en_US |
dc.subject |
reactions under pressure |
en_US |
dc.subject |
Q-tubes; polyaniline |
en_US |
dc.title |
Glycerol and Q-Tubes: |
en_US |
dc.title.alternative |
Green Catalyst and Technique for Synthesis of Polyfunctionally Substituted Heteroaromatics and Anilines |
en_US |
dc.type |
Article |
en_US |
dc.identifier.doi |
https://doi.org/10.3390/molecules24091806 |
|
dc.Affiliation |
October University for modern sciences and Arts (MSA) |
|