Hepatoprotective constituents of Torilis radiata Moench (Apiaceae)

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dc.contributor.author Ezzat, Shahira M
dc.contributor.author M Abdallah, Hossam
dc.contributor.author A Fawzy, Ghada
dc.contributor.author A El-Maraghy, Shohda
dc.date.accessioned 2019-11-04T06:41:43Z
dc.date.available 2019-11-04T06:41:43Z
dc.date.issued 2012
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dc.identifier.other https://doi.org/
dc.identifier.uri https://cutt.ly/KtwkrJd
dc.description MSA Google Scholar
dc.description.abstract An investigation of the aqueous ethanolic extract (AE) of the aerial parts of Torilis radiata Moench yielded two triterpenes (lupeol acetate 1 and α-amyrin 2), a sterol (spinasterol 3) from its n-hexane fraction (HF), a flavone (acacetin 4), a coumarin (scopoletin 5), a phenolic acid (ferulic acid 6) from the chloroform fraction (CF) and a flavone glycoside (luteolin-7- O-glucoside 7) from the n-butanol fraction (BF). The hepatoprotection of the AE and its fractions was assessed in terms of the reduction in histological damage, accompanied by restoration of the liver enzymes (alanine amino transferase (ALT), aspartate amino transferase (AST), lactate dehydrogenase (LDH)), a reduction in the inflammatory markers (tumour necrosis-α (TNF-α), nitric oxide (NO), N-acetyl-β-D-glucosaminidase (NAG) and myloperoxidase (MPO) in serum), and a restoration of the oxidant balance through decreasing the serum and hepatic malondialdehyde (MDA) levels, along with increasing the activity of hepatic catalase (CAT), glutathione peroxidase (GSHPx) and the non-enzymatic antioxidant glutathione (GSH). en_US
dc.description.sponsorship Taylor & Francis Group en_US
dc.description.uri https://www.scimagojr.com/journalsearch.php?q=24819&tip=sid&clean=0
dc.language.iso en en_US
dc.publisher Taylor & Francis Group en_US
dc.relation.ispartofseries Natural product research;26:3 , 282-285
dc.subject antioxidant en_US
dc.subject anti-inflammatory en_US
dc.subject hepatoprotective en_US
dc.subject Torilis radiata en_US
dc.title Hepatoprotective constituents of Torilis radiata Moench (Apiaceae) en_US
dc.type Article en_US
dc.identifier.doi https://doi.org/
dc.Affiliation October University for modern sciences and Arts (MSA)

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