Abstract:
Autophagy is a very well-conserved self-digestive mechanism that
transports unwanted or disposable cytoplasmic debris to lysosomes for destruction, including misfolded proteins and damaged
organelles. Advanced liver illnesses can develop from the prevalent
clinical condition known as non-alcoholic steatohepatitis (NASH).
There is no effective treatment, is still unclear. Therefore, in order
to create novel therapeutics, it is necessary to comprehend the
pathogenic pathways causing disease onset and progression.
Natural components from medicinal plants are currently the subject of a larger number of studies since they provide fresh promise
for NASH. This review provided an overview of the aetiology of
NASH, in addition the role of natural products as alternative or
complementary therapeutic agent for management of NASH via
autophagy induction. It was concluded that, alternative and complementary supplement of natural functional food as Arabica coffee that rich with chlorogenic acid targeting autophagy mechanism
mediate amelioration effect of NASH.
