dc.contributor.author |
Zayed, Ahmed |
|
dc.contributor.author |
Salem, Mohamed A |
|
dc.contributor.author |
Negm, Walaa A |
|
dc.contributor.author |
Ezzat, Shahira M |
|
dc.date.accessioned |
2023-05-26T08:01:46Z |
|
dc.date.available |
2023-05-26T08:01:46Z |
|
dc.date.issued |
2023-05 |
|
dc.identifier.other |
https://doi.org/10.1007/s43450-023-00403-9 |
|
dc.identifier.uri |
http://repository.msa.edu.eg/xmlui/handle/123456789/5584 |
|
dc.description.abstract |
Fever is a complicated process that occurs in response to infection and infammatory diseases, stimulating the immune
system that may cause severe biological changes in the human body. Hence, anti-pyretic agents are prescribed to reduce
elevated body temperature in order to maintain thermal homeostasis and protect the brain from damage. Additionally, there
is always a growing need for safe and efective anti-pyretic drugs derived from natural products, especially that anti-pyretic
pathways have been investigated well in previous literature. Many animal models are established for assessing anti-pyretic
candidates resulting in two types of anti-pyretics. They are the endogenous anti-pyretics that act as a defense mechanism for
temperature regulation and the exogenous anti-pyretics. The current article discusses the main anti-pyretic pathways, models
for assessing anti-pyretics, metabolomics applications in anti-pyretic assays, and screening of anti-pyretic and analgesic
natural products. Screening of plant-derived natural products and active principles with anti-pyretic, anti-infammatory,
and analgesic activities, in addition to their mechanism of action and validation methods, is described in the current article.
Hence, this review could contribute to the introduction of a site-specifc and safe naturally derived anti-pyretic medications
with potential therapeutic qualities compared to currently available synthetic anti-pyretics. |
en_US |
dc.description.uri |
https://www.scimagojr.com/journalsearch.php?q=5400152628&tip=sid&clean=0 |
|
dc.language.iso |
en_US |
en_US |
dc.publisher |
Springer Nature Switzerland AG |
en_US |
dc.relation.ispartofseries |
Revista Brasileira de Farmacognosia; |
|
dc.subject |
Animal models · |
en_US |
dc.subject |
Anti-pyretic pathways · |
en_US |
dc.subject |
Fever · |
en_US |
dc.subject |
Metabolomics · |
en_US |
dc.subject |
Plant sources · |
en_US |
dc.subject |
Active principles · |
en_US |
dc.subject |
Validation |
en_US |
dc.title |
Validation of Anti‑pyretic‑Derived Natural Products and Their Potentials for Drug Discovery |
en_US |
dc.type |
Article |
en_US |
dc.identifier.doi |
https://doi.org/10.1007/s43450-023-00403-9 |
|
dc.Affiliation |
October university for modern sciences and Arts MSA |
|