dc.contributor.author |
Elfert, Ashraf Y |
|
dc.contributor.author |
Salem, Amel |
|
dc.contributor.author |
Abdelhamid, Amr M |
|
dc.contributor.author |
Salama, Ahmad |
|
dc.contributor.author |
Sourour, Doaa A |
|
dc.contributor.author |
Shaker, Olfat |
|
dc.contributor.author |
Keshk, Mofida |
|
dc.date.accessioned |
2022-05-18T07:11:10Z |
|
dc.date.available |
2022-05-18T07:11:10Z |
|
dc.date.issued |
2022-05 |
|
dc.identifier.other |
https://doi.org/10.3389/fmolb.2022.864839 |
|
dc.identifier.uri |
http://repository.msa.edu.eg/xmlui/handle/123456789/4945 |
|
dc.description.abstract |
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related deaths worldwide with chronic hepatitis C virus (HCV) infection as a major risk factor of HCC. Circulating microRNAs are deregulated in HCC and are candidate biomarkers. The aim of this study was to explore the expression profile of miRNA-122, miR-483, and miR- 335 in the serum of HCV-related hepatocellular carcinoma (HCC). 90 HCV-related hepatocellular carcinoma (HCC) patients, 90 non-malignant HCV patients, and 60 healthy controls were included. Serum microRNAs were measured by a qRT-PCR custom array. The expression levels of miR-122 and miR-483 were upregulated in HCC patients, while the miR-335 expression level was downregulated versus controls and HCV groups. Receiver-operating characteristic (ROC) curve analysis was created to examine miRNAs. miR-483 presented the best diagnostic potential because it showed the highest diagnostic accuracy for distinguishing HCV-related HCC patients from controls (AUC = 0.98) with 100% sensitivity. Moreover, there was obvious prognostic power in distinguishing HCV from HCC (AUC = 0.95) with 88% sensitivity. In conclusion, studied microRNAs (miR-122, miR-483, and miR-335) could serve as potential non-invasive early diagnostic biomarkers for HCC, and we identified a panel of three serum microRNAs with high accuracy in HCC diagnosis. Additional studies are required to confirm this panel and test its prognostic significance. |
en_US |
dc.description.uri |
https://www.scimagojr.com/journalsearch.php?q=21100843667&tip=sid&clean=0 |
|
dc.language.iso |
en_US |
en_US |
dc.publisher |
Frontiers |
en_US |
dc.relation.ispartofseries |
Frontiers in Molecular Biosciences;May 2022 | Volume 9 | Article 864839 |
|
dc.subject |
HCV |
en_US |
dc.subject |
HCC |
en_US |
dc.subject |
miRNA-122 |
en_US |
dc.subject |
miRNA-483 |
en_US |
dc.subject |
miRNA-335 |
en_US |
dc.title |
Implication of miR-122, miR-483, and miR-335 Expression Levels as Potential Signatures in HCV-Related Hepatocellular Carcinoma (HCC) in Egyptian Patients |
en_US |
dc.type |
Article |
en_US |
dc.identifier.doi |
https://doi.org/10.3389/fmolb.2022.864839 |
|
dc.Affiliation |
October University for modern sciences and Arts (MSA) |
|