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| dc.contributor.author | Ezzat, Shahira M | |
| dc.contributor.author | M. Salama, Maha | |
| dc.contributor.author | Salah El Dine, Riham | |
| dc.contributor.author | M. El-Sayed, Aly | |
| dc.contributor.author | A. Sleem, Amany | |
| dc.date.accessioned | 2019-10-21T07:35:31Z | |
| dc.date.available | 2019-10-21T07:35:31Z | |
| dc.date.issued | 2013 | |
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S., and Rodrigues-Filho E. (2005), Lanostane triterpenes from the fungus Pisolithus tinctorius. J. Braz. Chem. Soc. 16, 863 – 867. Zhou L., Zhang Y., Gapter L. A., Ling H., Agarwal R., and Ng K. Y. (2008), Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos. Chem. Pharm. Bull. (Tokyo) 56, 1459 – 1462. | en_US |
| dc.identifier.other | https://doi.org/ | |
| dc.identifier.uri | https://cutt.ly/WteapuG | |
| dc.description.abstract | Applying a bioactivity-guided isolation strategy for the ethanolic extract of crown gall tumours induced on an Eucalyptus tereticornis tree, two new compounds in addition to a known one were isolated. The new compounds were identifi ed as an amino acid derivative named 1-ethyl-6-(1'-methyl-1'-phenylethyl) piperidin-2-one (1) and a lanostane tetracyclic triterpene named 3β-hydroxy-24-methyllanosta-8,17(20),24(28)-trien-22-oic acid (2), together with stigmasterol-3-O-glucoside (3). The three compounds exhibited signifi cant cytotoxic activity against two human cell lines, breast (MCF7) and colon (HCT116), with IC50 values of 1.01, 1.54, and 2.15 μg/ml, respectively, against MCF7 and 3.49, 3.83, and 3.39 μg/ ml, respectively, against HCT116. Furthermore, in rats elevated levels of blood cholesterol, triglycerides, and low-density lipoprotein (LDLc) were signifi cantly reduced, while the level of high-density lipoprotein (HDLc) was signifi cantly increased by administration of the etha nolic extract as well as of 3. These results support a correlation between the reduction of blood cholesterol levels and improvement of colorectal cancer. | en_US |
| dc.description.sponsorship | Zeitschrift für Naturforschung | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=14954&tip=sid&clean=0 | |
| dc.language.iso | en | en_US |
| dc.publisher | Zeitschrift für Naturforschung | en_US |
| dc.relation.ispartofseries | Z. Naturforsch.;68 | |
| dc.subject | University of New Amino Acid Derivatives | en_US |
| dc.subject | Crown Gall | en_US |
| dc.title | New Bioactive Metabolites from a Crown Gall Induced on an Eucalyptus tereticornis Sm. Tree | en_US |
| dc.type | Article | en_US |
| dc.description.version | MSA Google Scholar | |
| dc.identifier.doi | https://doi.org/ | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
