In vitro and in vivo Anticholinesterase Activity of the Volatile Oil of the Aerial Parts of Ocimum basilicum L. and O. africanum Lour. Growing in Egypt

Ezzat, Shahira M; G. Tadros, M.; M. Salama, M.; A. Farag, M.

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dc.contributor.author	Ezzat, Shahira M
dc.contributor.author	G. Tadros, M.
dc.contributor.author	M. Salama, M.
dc.contributor.author	A. Farag, M.
dc.date.accessioned	2019-10-20T10:49:30Z
dc.date.available	2019-10-20T10:49:30Z
dc.date.issued	2014
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dc.identifier.other	https://doi.org/
dc.identifier.uri	http://central-library.msa.edu.eg:8009/xmlui/handle/123456789/442
dc.description.abstract	In this study, the in vitro anticholinesterase activity of the volatile oils of both O. basilicum and O. africanum was investigated and both samples showed significant activity. The major constituents of the two oils were isolated using several column chromatographies. Linalool, 1,8-cineol and eugenol were isolated from the volatile oil of O. basilicum and camphor was isolated from the volatile oil of O. africanum. The anticholinesterase activities of the isolated compounds were also evaluated where 1,8-cineol showed the highest inhibitory activity followed by camphor. To confirm these activities, learning and memory enhancing effects were tested in mice. Memory impairment was induced by scopolamine, a cholinergic muscarinic receptor antagonist. Anti-amnesic effects of both volatile oils and their terpenoids were investigated by the passive avoidance task in mice. We also examined their effects on brain acetylcholinesterase activity. Results showed that scopolamineinduced cognitive dysfunction was significantly attenuated by administration of the volatile oils and their terpenoids, eugenol and camphor, in the passive avoidance task and inhibited brain acetylcholinesterase activity. These results suggest that O. basilicum and O. africanum volatile oils can be good candidates for further studies on Alzheimer’s disease via their acetylcholinesterase inhibitory actions.	en_US
dc.description.sponsorship	World Academy of Science, Engineering and Technology International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering	en_US
dc.description.uri	https://www.scimagojr.com/journalsearch.php?q=21100197994&tip=sid&clean=0
dc.language.iso	en	en_US
dc.publisher	World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering	en_US
dc.relation.ispartofseries	World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering;3
dc.subject	University of Acetylcholinesterase	en_US
dc.subject	Ocimum basilicum	en_US
dc.title	In vitro and in vivo Anticholinesterase Activity of the Volatile Oil of the Aerial Parts of Ocimum basilicum L. and O. africanum Lour. Growing in Egypt	en_US
dc.type	Article	en_US
dc.identifier.doi	https://doi.org/
dc.Affiliation	October University for modern sciences and Arts (MSA)