Gas chromatography-mass spectrometry analysis, hepatoprotective and antioxidant activities of the essential oils of four Libyan herbs

EL-Hawary, S.; EL-Shabrawy, A.; Ezzat, Shahira M; EL-Shibany, F.

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dc.contributor.author	EL-Hawary, S.
dc.contributor.author	EL-Shabrawy, A.
dc.contributor.author	Ezzat, Shahira M
dc.contributor.author	EL-Shibany, F.
dc.date.accessioned	2019-10-20T07:02:50Z
dc.date.available	2019-10-20T07:02:50Z
dc.date.issued	2013
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dc.identifier.issn	1996-0875
dc.identifier.other	https://doi.org/10.5897/JMPR2013.4430
dc.identifier.uri	https://cutt.ly/utwj7kM
dc.description	MSA Google Scholar
dc.description.abstract	Following an ethnobotanical survey for hepatoprotective remedies, four Libyan medicinal plants from family Lamiaceae; Ajuga iva (L.) Schreber, Marrubium vulgare L., Rosmarinus officinalis L. and Thymus capitatus Hoff. et Link growing widely in Beida, Libya, were selected for our study. The chemical composition of essential oils hydrodistilled from the dried aerial parts, were analyzed by gas chromatography-mass spectrometry (GC-MS). The major constituents of the essential oils of A. iva and R. officinalis were carvacrol (35.07%) and 1,8-cineol (35.21%), respectively, thymol was the major constituent of the essential oil of M. vulgare (20.11%) and T. capitatus (90.15%). The oil of M. vulgare had the most powerful antioxidant activity by restoring glutathione levels in the blood of alloxan-induced diabetic rats. The rats treated with the essential oils of M. vulgare, R. officinalis and T. capitatus (50 mg/kg) showed a significant decrease in liver enzymes which were elevated by CCl4 (p ˂ 0.01). The essential oil of M. vulgare had the most potent hepatoprotective activity.	en_US
dc.description.sponsorship	Journal of Medicinal Plants Research	en_US
dc.language.iso	en	en_US
dc.publisher	Journal of Medicinal Plants Research	en_US
dc.relation.ispartofseries	JMPR;24
dc.subject	University of Marrubium vulgare	en_US
dc.subject	Rosmarinus officinalis	en_US
dc.title	Gas chromatography-mass spectrometry analysis, hepatoprotective and antioxidant activities of the essential oils of four Libyan herbs	en_US
dc.type	Article	en_US
dc.identifier.doi	https://doi.org/10.5897/JMPR2013.4430
dc.Affiliation	October University for modern sciences and Arts (MSA)