dc.contributor.author |
Wasfi, Reham |
|
dc.contributor.author |
Rasslan, Fatma |
|
dc.contributor.author |
Hassan, Safaa S. |
|
dc.contributor.author |
Ashour, Hossam M. |
|
dc.contributor.author |
Abd El-Rahman, Ola A. |
|
dc.date.accessioned |
2020-11-18T09:06:23Z |
|
dc.date.available |
2020-11-18T09:06:23Z |
|
dc.date.issued |
11/12/2020 |
|
dc.identifier.other |
https://doi.org/10.1007/s40121-020-00369-4 |
|
dc.identifier.uri |
http://repository.msa.edu.eg/xmlui/handle/123456789/4204 |
|
dc.description.abstract |
Introduction: Acinetobacter baumannii is an
opportunistic pathogen, which can acquire new
resistance genes. Infections by carbapenem-re-
sistant A. baumannii (CRAB) in cancer patients
cause high mortality.
Methods: CRAB isolates from cancer patients
were screened for carbapenemase-encoding
genes that belong to Ambler classes (A), (B), and
(D), followed by genotypic characterization by
enterobacterial-repetitive-Intergenic-
consensus–polymerase chain reaction
(ERIC–PCR) and multilocus-sequence-typing
(MLST).
Results: A total of 94.1% of CRAB isolates co-
harbored more than one carbapenemase-en-
coding gene. The genes blaNDM, blaOXA-23-like,
and blaKPC showed the highest prevalence, with
rates of 23 (67.7%), 19 (55.9%), and 17 (50%),
respectively. ERIC-PCR revealed 19 patterns
(grouped into 9 clusters). MLST analysis identi-
fied different sequence types (STs) (ST-268, ST-
195, ST-1114, and ST-1632) that belong to the
highly resistant easily spreadable International
clone II (IC II). Genotype diversity indicated
the dissemination of carbapenem-hydrolyzing,
b-lactamase-encoding genes among genetically
unrelated isolates. We observed a high preva-
lence of metallo-b-lactamase (MBL)-encoding
genes (including the highly-resistant blaNDM
gene that is capable of horizontal gene transfer)
and of isolates harboring multiple carbapene-
mase-encoding genes from different classes.
Conclusion: The findings are alarming and call
for measures to prevent and control the spread
of MBL-encoding genes among bacteria causing
infections in cancer patients and other
immunocompromised patient populations. |
en_US |
dc.description.uri |
https://www.scimagojr.com/journalsearch.php?q=21100466856&tip=sid&clean=0 |
|
dc.language.iso |
en_US |
en_US |
dc.publisher |
ADIS |
en_US |
dc.relation.ispartofseries |
Infectious Diseases and Therapy ·;November 2020 |
|
dc.subject |
Multilocus sequence typing (MLST) |
en_US |
dc.subject |
Metallo-b- lactamase (MBL) |
en_US |
dc.subject |
Carbapenem-resistant Acinetobacter baumannii (CRAB) |
en_US |
dc.subject |
Cancer |
en_US |
dc.title |
Co-Existence of Carbapenemase-Encoding Genes in Acinetobacter baumannii from Cancer Patients |
en_US |
dc.type |
Article |
en_US |
dc.identifier.doi |
https://doi.org/10.1007/s40121-020-00369-4 |
|
dc.Affiliation |
October University for modern sciences and Arts (MSA) |
|