Abstract:
Three labdane diterpenes, namely labda-8(17),14-diene, 13-epicupressic acid, and 13-Oacetyl-
13-epicupressic acid, were isolated from the resin collected from stem exudates of
Araucaria heterophylla Salisb. (Araucariaceae). The isolated compounds were identifi ed
using different spectroscopic methods (1H NMR, 13C NMR, HMQC, HMBC and COSY).
The resin extract showed antiulcerogenic activity against ethanol-induced stomach ulcers
in Sprauge Dawely rats using ranitidine as standard. In addition, the resin and the isolated
compounds showed variable cytotoxic activities against breast (MCF7) and colon (HCT116)
cancer cell lines.
