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| dc.contributor.author | M. Fouad, Manal | |
| dc.contributor.author | S. Rashed, Noha | |
| dc.date.accessioned | 2019-10-19T08:47:47Z | |
| dc.date.available | 2019-10-19T08:47:47Z | |
| dc.date.issued | 2014 | |
| dc.identifier.citation | 1. Neil J. O., The Merck index, 13th ed., pharmaceutical Press, London, UK; 2007 p. 5963,8220. 2. Hardman J.G., Limbard L.E., Goodman Gillman, "The pharmacological basis of therapeutics", 11th ed., Mc Graw Hill; 2005, pp.1704-1705. 3. Robert GM., Achieving glycosylated haemoglobin targets using the combination of repaglinide and metformin in type 2 diabetis, Clin Ther 30, 552- 554 (2008). 4. Rajput S.J. and Chaudhary B.G., Validated analytical methods of repaglinide in bulk and tablet formulation, Indian Journal of Pharmaceutical Science, 68(5), 656-657 (2006). 5. Ruzilawati A. B., Zabidah I. and Siew H. G., Method development and validation of repaglinide in human plasma by HPLC and its application in pharmacokinetic studies, J. Pharm. and Biomed. Anal., 43(5), 1831-1835 (2007). 6. Mubeen G., Khalikha N. and Vimala M., Spectrophotometric method for estimation of metformin hydrochloride., Int. J. ChemTech Res., 2(2), 1186-1187(2010). 7. Wanjari M. M. , There A. W., Tajne M. R. and Chopde C. T., Rapid and simple RP HPLC method for the estimation of metformin in rat plasma., Indian journal of pharmaceutical sciences, 70(2), 198-202 (2008).8. Madhukar A., Prince A., Vijay K. R., Sanjeeva Y. and Jagadeshwar K., Simple and sensitive analytical method development and validation of metformin hydrochloride by RP-HPLC., Int. Journal Pharm. Sci. 3, 117-120 (2011). 9. Mahipal M., Rajesh R., Parmar k., Vaishali N. and Dushyant A., Simultaneous estimation of metformin hydrochloride and repaglinide in pharmaceutical dosage form by UV difference spectrophotometric method., International journal of institutional pharmacy and life sciences 2(3), 38-47 (2012). 10. Patel D. R., Patel L. J. and Patel M. M., Stability indicating HPLC method for simultaneous determination of repaglinide and metformin hydrochloride in pharmaceutical dosage form., Assian Journal of Research In Chemistry 4, 500- 505 (2011). 11. Prasath V. G., Susamma C. E. and Amitha R. , Development and validation of UV spectroscopic methods for the estimation of repaglinide and metformin hydrochloride in synthetic mixture, International Journal of Pharmaceutical Science and Health Care, 2(2), 150-158 (2012). 12. Keyur B. A., Emanuel M. P. and Arpit S., Simultaneous estimation of metformin hydrochloride and repaglinide in pharmaceutical formulation by HPTLC-densitometry method, J. Chromat. Separation Techniq. 4(1), 1-5 (2013). 13. Bhaskar R. L. , Raveendra R. P., Useni R. M. and Maheshwara R. L., Novel PR-HPLC method for metformin hydrochloride, glipizide and repaglinide pharmaceutical drug products.International Journal Of Research And Reviews In Pharmacy And Applied Sciences, 1(3), 131-139 (2011). 14. International Conference on Harmonization, Validation of Analytical Procedures: Methodology, Federal Register, Nov.; 1996, 1-8. | en_US |
| dc.identifier.issn | 2230-7346 | |
| dc.identifier.other | https://doi.org/ | |
| dc.identifier.uri | http://central-library.msa.edu.eg:8009/xmlui/handle/123456789/396 | |
| dc.description.abstract | Two simple, accurate and reproducible methods have been developed for the determination of repaglinide and metformin as bulk or simultaneously in their combined dosage form. The first is a reversed phase HPLC method using C18 column, mobile phase consisting of methanol-0.2% heptane sulphonate sodium (70:30 v/v) at a flow rate of 1ml/min and UV detection at 240 nm. Beer's plot shows good correlations in the concentration range of 1-10 μgml-1 for both drugs. The second method is a derivative spectrophotometry, in which the two drugs were quantified using second derivative responses at 287 nm for repaglinide and at 234 or 252 nm for metformin with a linearity range of 5- 40 or 2-12 μgml-1 for the two drugs, respectively. The proposed methods were validated and successfully applied to the determination of both drugs in their pharmaceutical formulation with mean recoveries of 99.58-100.45 ± 0.386-0.931. The results obtained were statistically compared to those obtained from a reference method and were found to be in good agreement. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=21100853545&tip=sid&clean=0 | |
| dc.language.iso | en | en_US |
| dc.publisher | Journal of Global Trends in Pharmaceutical Sciences | en_US |
| dc.relation.ispartofseries | JGTPS,;Vol. 5(3): 1844- 1848 | |
| dc.subject | Repaglinide, metformin, | en_US |
| dc.subject | HPLC, | en_US |
| dc.subject | second-derivative | en_US |
| dc.subject | spectrophotometry, | en_US |
| dc.subject | pharmaceutical formulation. | en_US |
| dc.title | DEVELOPMENT AND VALIDATION OF CHROMATOGRAPHIC AND SPECTROSCOPIC METHODS FOR ESTIMATION OF REPAGLINIDE AND METFORMIN HCl IN COMBINED DOSAGE FORM | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | https://doi.org/ | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
