Abstract:
Diabetes being the most common chronic metabolic disorder has a
number of complications that affect various parts of the body.
Epidermal growth factor (EGF) is well known for its healing capacity.
In this article we review the two way relationship between diabetes
and EGF, where the former needs to block the latter’s secretion and
reduce its expression on order to produce its notorious
complications. On the contrary, the latter is capable of reversing the
former’s negative adverse effect on various organs of the body. We
also shed some light on different studies in the literature that
investigated the role of EGF in the dynamics of diabetes, and gain a
deeper insight towards the possible applications of local and
systemic treatment with EGF in the management of diabetic
complications. We also try to answer some questions: EGF and
diabetes; Friends or faux? and will EGF be the future trend in
reversing damage caused by diabetes and wound healing?
