Abstract:
Milk or milk component-based drinks seem to possess many of the
biological and physical properties desired for a saliva substitute. Milk
contains two primary sources of protein, the caseins and whey. Alpha-
Lactalbumin (α-LA) is one of the main proteins found in human and
bovine milk whey. Glycomacropeptide is a major component of casein
protein .α-La with antimicrobial properties have been reported as α-La
yielded bactericidal peptides. Both demonstrate a number of biological
activities in medicine not only as milk protein but also as natural
antibacterial.
Aim of the study: To examine the antibacterial activities of milk
proteins glycomacropeptide and alpha lactalbumin compared with
chlorhexidine and their effect on Mutans streptococci count in human
dental plaque samples from children.
Materials and methods: Twenty children patient were sampled as
follow six dental plaque samples were taken from each child from the
buccal surface of first permanent molars , by sterile dental excavator
and stored in Epindorff tube, then divided into six groups (Control
group, Chlorhexidine group, Alpha lactalbumin1% (αLA1%),
Alphalactalbumin2%(αLA2%,Casienglycomacropeptide1%(GMP1%),
Casienglycomacropeptide 2% (GMP 2%)) then Mutans Streptococci in
the plaque samples of tested children were evaluated using selective
media for mutans Streptococci.
Results: GMP 2% was the highest reduction followed GMP 1%, αLA
2% and αLA 1%.Conclusion: Alpha lactalbumin and
Casienglycomacropeptide had antibacterial effect on Mutans
Streptococci preset in dental plaque in children.
