Role of chemokine ligand 22 in narrow-band ultraviolet B-induced pigmentation in vitiligo: an immunohistochemical study

G Antar Farag, Azza; A Hammam, Mostafa; R Al-Sharaky, Dalia; A Hassan, Reem; N ElShafey, Eman; A Ali, Nehal

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Role of chemokine ligand 22 in narrow-band ultraviolet B-induced pigmentation in vitiligo: an immunohistochemical study

G Antar Farag, Azza; A Hammam, Mostafa; R Al-Sharaky, Dalia; A Hassan, Reem; N ElShafey, Eman; A Ali, Nehal

Full Text link: https://cutt.ly/ctjL3Ei

Date issued: 2019

Scientific Journal Rankings: Click Here

Doi: https://doi.org/10.4103/JEWD.JEWD_4_19

Publisher: Medknow Publications

Series Info: Journal of the Egyptian Women’s Dermatologic Society;VOL : 16 Issue : 2

Type: Article

Keywords: chemokine ligand 22 , narrow band ultraviolet B , vitiligo

Abstract:

Chemokine ligand 22 (CCL22) is a heparin-binding immunomodulator protein that plays an important role in a variety of autoimmune diseases. Narrow-band ultraviolet B (NB-UVB) therapy was considered a cornerstone in the treatment of vitiligo. However, the mechanism of action of NB-UVB in vitiligo has not been completely elucidated. Objective To study the hypothesized role of CCL22 in vitiligo etiopathogenesis and to detect its possible role in NB-UVB-induced pigmentation in vitiligo through its lesional immunohistochemical evaluation in patients with vitiligo before and after ultraviolet B phototherapy.