dc.contributor.author |
I Ezzat, Marwa |
|
dc.contributor.author |
Ezzat, Shahira M |
|
dc.contributor.author |
S El Deeb, Kadriya |
|
dc.contributor.author |
M El Fishawy, Ahlam |
|
dc.date.accessioned |
2020-03-04T06:25:31Z |
|
dc.date.available |
2020-03-04T06:25:31Z |
|
dc.date.issued |
2017 |
|
dc.identifier.issn |
1478-6419 |
|
dc.identifier.other |
https://doi.org/10.1080/14786419.2016.1239091 |
|
dc.identifier.uri |
https://cutt.ly/mteutzL |
|
dc.description |
MSA Google Scholar |
en_US |
dc.description.abstract |
Investigation of the ethanol extract of the corms of Liatris spicata (L.) willd led to the isolation of two sterols: stigmasterol and its 3-O-glucoside, a triterpene: obtusifoliyl acetate, two benzofurans: euparin and 6-hydroxy-3-methoxytremetone, three phenolic acids: protocatechuic, vanillic and ferulic acid and a sesquiterpene lactone igalan. The structures of the isolated compounds were established on the basis of physicochemical properties and spectral analysis (IR, EI/MS, 1H NMR and 13C NMR). The ethanol extract and its isolated compounds evidenced cytotoxic activities against human liver cancer cell line (HepG2), where igalan showed the highest potency (3.83 ± 0.043) μg/mL, its effect was comparable to that of the standard drug doxorubicin® (3.73 ± 0.036) μg/mL. |
en_US |
dc.description.sponsorship |
Taylor & Francis |
en_US |
dc.description.uri |
https://www.scimagojr.com/journalsearch.php?q=24819&tip=sid&clean=0 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Taylor & Francis |
en_US |
dc.relation.ispartofseries |
Natural product research;VOL : 31 Issue : 11 |
|
dc.subject |
Liatris Spicata |
en_US |
dc.subject |
Cytotoxic Activities |
en_US |
dc.subject |
Igalan |
en_US |
dc.title |
In vitro evaluation of cytotoxic activity of the ethanol extract and isolated compounds from the corms of Liatris spicata (L.) willd on HepG2 |
en_US |
dc.type |
Article |
en_US |
dc.identifier.doi |
https://doi.org/10.1080/14786419.2016.1239091 |
|
dc.Affiliation |
October University for modern sciences and Arts (MSA) |
|