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| dc.contributor.author | Omar Bakr, Riham | |
| dc.contributor.author | Abd El Halim Mohamed, Shaza | |
| dc.contributor.author | Ayoub, Nahla | |
| dc.date.accessioned | 2020-02-23T07:28:27Z | |
| dc.date.available | 2020-02-23T07:28:27Z | |
| dc.date.issued | 2016 | |
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| dc.identifier.other | https://doi.org/10.21010/ajtcam. v13i6.19 | |
| dc.identifier.uri | https://t.ly/1VM2E | |
| dc.description | MSA Google Scholar | en_US |
| dc.description.abstract | Background: Centaurea aegyptiaca L (Asteraceae), is one of the most attractive plants growing wildly in Sinai, and is not well investigated for its phytochemical constituents. This study represents the first in-depth characterization of the phenolic profile of the aerial parts of C. aegyptiaca methanolic extract utilizing liquid chromatography (LC) combined with electrospray ionization (ESI) tandem mass spectrometry (MS/MS). Material and Methods: Phenolic profile was researched utilizing LC-HRESI-MS-MS. Assessment of cytotoxic activity against four human cancer cell lines (Hep-G2; hepatocellular carcinoma cells, MCF-7; breast adenocarcinoma cells, and HCT-116; colon carcinoma and HELA; cervical carcinoma cells) was performed using 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Antiviral activity was surveyed utilizing cytopathic effect inhibition assay. Results: A total of sixty-one compounds were tentatively distinguished (twenty-one phenolic acids and their derivatives, thirty-one flavonols and nine flavones) in the negative and positive modes. Centaurea aegyptiaca demonstrated outstanding results against Hep-G2, MCF-7, HCT-116 and HELA cell lines with IC50 of 12.1, 30.9, 11.7 and 19.5 µg/mL respectively compared and doxorubicin as a reference drug. Weak antiviral activity was seen against hepatitis A virus (HAV) and no impact against herpes simplex virus type 1 (HSV 1). Conclusion: This study provides a better understanding of the chemistry of C. aegyptiaca that announces itself as a promising cytotoxic agent. | en_US |
| dc.description.sponsorship | African Ethnomedicines Network (Nigeria) | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=4700152608&tip=sid&clean=0 | |
| dc.language.iso | en | en_US |
| dc.publisher | African Ethnomedicines Network (Nigeria) | en_US |
| dc.relation.ispartofseries | African Journal of Traditional, Complementary and Alternative Medicines;Volume: 13 Issue: 6 Pages: 135-143 | |
| dc.subject | University of Centaurea aegyptiaca, Cytotoxicity, MTT assay, flavonoid. | en_US |
| dc.title | Phenolic profile of Centaurea aegyptiaca L. growing in Egypt and its cytotoxic and antiviral activities | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | https://doi.org/10.21010/ajtcam. v13i6.19 | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
