dc.contributor.author |
Sanad, MH |
|
dc.contributor.author |
Sakr, TM |
|
dc.contributor.author |
HA Abdel-Hamid, Walaa |
|
dc.contributor.author |
Marzook, EA |
|
dc.date.accessioned |
2020-02-13T08:16:08Z |
|
dc.date.available |
2020-02-13T08:16:08Z |
|
dc.date.issued |
2017 |
|
dc.identifier.issn |
0236-5731 |
|
dc.identifier.other |
https://doi.org/10.1007/s10967-016-5120-y |
|
dc.identifier.uri |
https://cutt.ly/PrLerZL |
|
dc.description |
MSA Google Scholar |
en_US |
dc.description.abstract |
The non-invasive quantification of AMPA receptors (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) could become a prognostic marker for brain disorders. 99mTc-tricarbonyl oxiracetam complex was prepared as a novel probe for AMPA receptor targeting with radiolabeling yield >98% and showed stability of 12 h. Molecular modeling and docking studies of 99mTc-tricarbonyl oxiracetam were performed. The results suggested that the complex act as very good positive allosteric modulators for AMPA receptor. The biodistribution studies revealed high brain uptake (7.5 ± 0.11% %ID/g) at 5 min post-I.V. injection that make 99mTc-tricarbonyl oxiracetam as a novel brain perfusion imaging radiotracer. |
en_US |
dc.description.sponsorship |
Springer |
en_US |
dc.description.uri |
https://www.scimagojr.com/journalsearch.php?q=24060&tip=sid&clean=0 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
SPRINGER |
en_US |
dc.relation.ispartofseries |
Journal of Radioanalytical and Nuclear Chemistry;VOL : 314 Issue : 3 |
|
dc.subject |
99mTc-tricarbonyl |
en_US |
dc.subject |
Oxiracetam |
en_US |
dc.subject |
Biodistribution |
en_US |
dc.subject |
Brain imaging |
en_US |
dc.subject |
AMPA receptor |
en_US |
dc.subject |
Molecular modeling and docking studies |
en_US |
dc.title |
In silico study and biological evaluation of 99mTc-tricabonyl oxiracetam as a selective imaging probe for AMPA receptors |
en_US |
dc.type |
Article |
en_US |
dc.identifier.doi |
https://doi.org/10.1007/s10967-016-5120-y |
|
dc.Affiliation |
October University for modern sciences and Arts (MSA) |
|