dc.contributor.author |
Swidan, MM |
|
dc.contributor.author |
Sakr, TM |
|
dc.contributor.author |
Motaleb, MA |
|
dc.contributor.author |
Abd El‐Bary, A |
|
dc.contributor.author |
El‐Kolaly, MT |
|
dc.date.accessioned |
2020-02-13T07:48:27Z |
|
dc.date.available |
2020-02-13T07:48:27Z |
|
dc.date.issued |
2014 |
|
dc.identifier.issn |
1099-1344 |
|
dc.identifier.other |
https://doi.org/10.1002/jlcr.3223 |
|
dc.identifier.uri |
https://cutt.ly/HrLqMhl |
|
dc.description |
MSA Google Scholar |
en_US |
dc.description.abstract |
Acebutolol was successfully labeled with 125I via direct electrophilic substitution reaction. Radioiodinated acebutolol was prepared with a maximum radiochemical yield of 96.5 ± 0.3% and in vitro stability up to 72 h. The in vivo biological distribution of radioiodinated acebutolol showed high heart uptake of 37.8 ± 0.14% injected activity/g organ with low lungs and liver uptakes at 5 min post‐injection. In vivo receptor blocking study was carried out in mice to evaluate its selectivity to heart. Radioiodinated acebutolol showed fast heart accumulation with high heart/liver ratio, which provides the ability for fast myocardial imaging with significant decrease in the radiation hazards risk on patients. So, radioiodinated acebutolol could be displayed as a radiotracer drug of choice in case of emergency patients for myocardial perfusion imaging. |
en_US |
dc.description.sponsorship |
Wiely |
en_US |
dc.description.uri |
https://www.scimagojr.com/journalsearch.php?q=24043&tip=sid&clean=0 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Journal of Labelled Compounds and Radiopharmaceuticals |
en_US |
dc.relation.ispartofseries |
Journal of Labelled Compounds and Radiopharmaceuticals;VOL : 57 Issue : 10 |
|
dc.subject |
myocardial perfusion imaging |
en_US |
dc.subject |
radioiodination |
en_US |
dc.subject |
acebutolol |
en_US |
dc.subject |
chloramin‐T |
en_US |
dc.title |
Radioiodinated acebutolol as a new highly selective radiotracer for myocardial perfusion imaging |
en_US |
dc.type |
Article |
en_US |
dc.identifier.doi |
https://doi.org/10.1002/jlcr.3223 |
|
dc.Affiliation |
October University for modern sciences and Arts (MSA) |
|