dc.contributor.author |
Swidan, MM |
|
dc.contributor.author |
Sakr, TM |
|
dc.contributor.author |
Motaleb, MA |
|
dc.contributor.author |
Abd El-Bary, A |
|
dc.contributor.author |
El-Kolaly, MT |
|
dc.date.accessioned |
2020-02-13T07:13:46Z |
|
dc.date.available |
2020-02-13T07:13:46Z |
|
dc.date.issued |
2015 |
|
dc.identifier.issn |
0236-5731 |
|
dc.identifier.other |
https://doi.org/10.1007/s10967-014-3328-2 |
|
dc.identifier.uri |
https://cutt.ly/OrK5vPS |
|
dc.description |
MSA Google Scholar |
en_US |
dc.description.abstract |
Radioiodinated fenoterol and reproterol were prepared by electrophilic radioiodination reaction using chloramin-T as oxidizing agent with radiochemical yields of 97.7 ± 0.7 and 95.2 ± 0.3 %, respectively, and in vitro stability up to 72 h. Biodistribution study performed in male Albino Swiss mice showed maximum radioactivity accumulation in lungs tissue to the extent of 52 ± 1.03 and 50.6 ± 1.2 % ID/g at 15 and 30 min post injection (p.i.) for radioiodinated fenoterol and reproterol, respectively, with low accumulation in heart and blood. The clearance pathway of both iodo-compounds was through renal and hepatobiliary routes. The selectivity of iodo-compounds to lung was examined by in vivo receptor blocking study. Radioiodinated fenoterol and reproterol are not a blood products and so they are more safer than the currently available 99mTc-MAA, and their lungs uptake is higher than that of the recently discovered 125/123I-IPMPD, 99mTc(CO)5I, 99mTc-DHPM and 125/123I-paroxetine. So, radioiodinated fenoterol and reproterol could be introduced as a new compromising radiopharmaceuticals for lung perfusion scintigraphy more safe than the currently available 99mTc-MAA and more potential than the recently discovered 125/123I-IPMPD, 99mTc(CO)5I, 99mTc-DHPM and 125/123I-paroxetine |
en_US |
dc.description.sponsorship |
Springer |
en_US |
dc.description.uri |
https://www.scimagojr.com/journalsearch.php?q=24060&tip=sid&clean=0 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
SPRINGER |
en_US |
dc.relation.ispartofseries |
Journal of Radioanalytical and Nuclear Chemistry;VOL : 303 Issue : 1 |
|
dc.subject |
Fenoterol |
en_US |
dc.subject |
Reproterol |
en_US |
dc.subject |
Radioiodination |
en_US |
dc.subject |
Chloramin-T |
en_US |
dc.subject |
Radioiodination Chloramin-T |
en_US |
dc.subject |
Lung perfusion scanning |
en_US |
dc.title |
Preliminary assessment of radioiodinated fenoterol and reproterol as potential scintigraphic agents for lung imaging |
en_US |
dc.type |
Article |
en_US |
dc.identifier.doi |
https://doi.org/10.1007/s10967-014-3328-2 |
|
dc.Affiliation |
October University for modern sciences and Arts (MSA) |
|