Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m

Ibrahim Al-Wabli, Reem; Mostafa Mohamed Hafez Sakr, Tamer; Abdou Khedr, Mohammed; Abdallah Selim, Adly; Abd El-Motaleb Abd El, Mohamed; Abdou Zaghary, Wafaa

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Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m

Ibrahim Al-Wabli, Reem; Mostafa Mohamed Hafez Sakr, Tamer; Abdou Khedr, Mohammed; Abdallah Selim, Adly; Abd El-Motaleb Abd El, Mohamed; Abdou Zaghary, Wafaa

Full Text link: https://cutt.ly/prK82JD

Date issued: 2016

Scientific Journal Rankings: Click Here

Doi: https://doi.org/10.1186/s13065-016-0220-x

Publisher: BIOMED CENTRAL LTD

Series Info: Chemistry Central Journal;VOL : 10 Issue : 1

Type: Article

Keywords: Platelet-12 lipoxygenase , Curcumin , Technetium-99m , Cancer imaging , Enzyme targeting , Docking

Abstract:

One of the most popular techniques for cancer detection is the nuclear medicine technique. The present research focuses on Platelet-12-lipoxygenase (P-12-LOX) as a promising target for treating and radio-imaging tumor tissues. Curcumin was reported to inhibit this enzyme via binding to its active site