dc.contributor.author |
Sakr, TM |
|
dc.contributor.author |
El‐Safoury, DM |
|
dc.contributor.author |
AS Awad, Gehanne |
|
dc.contributor.author |
Motaleb, MA |
|
dc.date.accessioned |
2020-02-12T08:45:14Z |
|
dc.date.available |
2020-02-12T08:45:14Z |
|
dc.date.issued |
2013 |
|
dc.identifier.issn |
1099-1344 |
|
dc.identifier.other |
https://doi.org/10.1002/jlcr.3060 |
|
dc.identifier.uri |
https://cutt.ly/nrJIFkL |
|
dc.description |
MSA Google Scholar |
en_US |
dc.description.abstract |
Tyrosine kinases are groups of enzymes, which are over‐expressed in solid tumor cells, representing good targets for different drugs such as sunitinib (N‐[2‐(diethylamino)ethyl]‐5‐{[(3Z)‐5‐fluoro‐2‐oxo‐2,3‐dihydro‐1H‐indol‐3‐ylidene]methyl}‐2,4‐dimethyl‐1H‐pyrrole‐3‐carboxamide). The aim of this work was to design and synthesize 99mTc‐sunitinib radiotracer and to study its tumor binding specificity as a novel selective radiopharmaceutical for tumor hypoxia imaging. The in vivo biodistribution of 99mTc‐sunitinib in tumor bearing mice showed high target/non‐target (T/NT) ratio (T/NT ~ 3 at 60 min post injection). This preclinical high biological accumulation in tumor cells suggests that 99mTc‐sunitinib is ready to go through the clinical trials as a potential selective radiotracer able to image tumor hypoxia. |
en_US |
dc.description.sponsorship |
Wiley |
en_US |
dc.description.uri |
https://www.scimagojr.com/journalsearch.php?q=24043&tip=sid&clean=0 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
WILEY |
en_US |
dc.relation.ispartofseries |
Journal of Labelled Compounds and Radiopharmaceuticals;VOL : 56 Isssue : 8 |
|
dc.subject |
sunitinib |
en_US |
dc.subject |
technetium‐99 m |
en_US |
dc.subject |
SPECT |
en_US |
dc.subject |
Tumor |
en_US |
dc.subject |
imaging |
en_US |
dc.subject |
hypoxia |
en_US |
dc.title |
Biodistribution of 99mTc‐sunitinib as a potential radiotracer for tumor hypoxia imaging |
en_US |
dc.type |
Article |
en_US |
dc.identifier.doi |
https://doi.org/10.1002/jlcr.3060 |
|
dc.Affiliation |
October University for modern sciences and Arts (MSA) |
|