Browsing Faculty Of Pharmacy Research Paper by Author "Faculty of Life and Social Sciences"

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Assessment of new anti-HER2 ligands using combined docking, QM/MM scoring and MD simulation

Ahmed M.; Sadek M.M.; Serrya R.A.; Kafafy A.-H.N.; Abouzid K.A.; Wang F. (2013)

In the development of new anti-cancer drugs to tackle the problem of resistance to current chemotherapeutic agents, a new series of anti-HER2 (human epidermal growth factor receptors 2) agents has been synthesized and ...
Discovery of new HER2/EGFR dual kinase inhibitors based on the anilinoquinazoline scaffold as potential anti-cancer agents

Sadek M.M.; Serrya R.A.; Kafafy A.-H.N.; Ahmed M.; Wang F.; Abouzid K.A.M. (Informa Healthcare, 2014)

Herein, we designed and synthesized certain anilinoquinazoline derivatives bearing bulky arylpyridinyl, arylpropenoyl and arylpyrazolyl moieties at the 4? position of the anilinoquinazoline, as potential dual HER2/EGFR ...
In silico design: Extended molecular dynamic simulations of a new series of dually acting inhibitors against EGFR and HER2

Ahmed M.; Sadek M.M.; Abouzid K.A.; Wang F. (Elsevier Inc., 2013)

Based on the hit structures that have been identified in our previous studies against EGFR and HER2, new potential inhibitors that share the same scaffold of the hit structures are designed and screened in silico. Insights ...

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