Complement factor H polymorphism rs1061170 and the effect of cigarette smoking on the risk of lung cancer

Ezzeldin, Nada; El-Lebedy, Dalia; Darwish, Amira; El-Bastawissy, Ahmed; Shalaby, Alaa Eldin

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Complement factor H polymorphism rs1061170 and the effect of cigarette smoking on the risk of lung cancer

Ezzeldin, Nada; El-Lebedy, Dalia; Darwish, Amira; El-Bastawissy, Ahmed; Shalaby, Alaa Eldin

Full Text link: https://cutt.ly/crYaxFm

Date issued: 2015

Doi: https://doi.org/0.5114/wo.2015.56202

Publisher: Termedia Publishing

Series Info: Contemporary Oncolog;VOL : 19 ISU : 6

Type: Article

Keywords: complement , factor H , Lung cancer , polymorphism , Smoking

Abstract:

Complement factor H (CFH) has been known to inhibit the complement pathway and to contribute to tumour growth by suppressing the anti-tumour cell mediated response in cell lines from several malignancies. We examined the association of Try402His single nucleotide polymorphism in CFH gene with lung cancer and the interaction with cigarette smoking.