Synthesis of hydrazide-hydrazone derivatives and their evaluation of antidepressant, sedative and analgesic agents
Mohareb R.M.; El-Sharkawy K.A.; Hussein M.M.; El-Sehrawi H.M.
Date issued:
2010
Series Info:
Journal of Pharmaceutical Sciences and Research
2
Type:
Article
Keywords:
1,3,4-triazine
,
Antidepressant
,
Hydrazide-hydrazone
,
Pyridine
,
Sedative
,
3 cyano 4,6 dimethyl 2 oxo 1 imino (4 methoxy omega hydrazinoacetophenonylidieno)pyridine
,
3 cyano 6 hydroxy 4 methyl 2 oxo 1 imino(4 methoxy omega hydrazinoacetophenoylidieno)pyridine
,
4 amino 5 h 6 (4 methoxyphenyl) 3 (alpha phenylhydrazoacetonitrilo) 1,2,4 triazine
,
4 amino 5 h 6 (4 methoxyphenyl) 3 [alpha (3 cyano 2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiophene)acetonitrilo] 1,2,4 triazine
,
4 methoxy omega bromoacetophenone cyanoacetylhydrazone
,
4 methoxy omega cyanoacetophenone cyanoacetylhydrazone
,
4 methoxy omega hydrazinoacetophenone cyanoacetylhydrazone
,
4 methoxy omega phenylhydrazinoacetophenone cyanoacetylhydrazone
,
4 methoxy omega thiocyanoacetophenone cyanoacetylhydrazone
,
4 phenylamino 5 h 6 (4 methoxyphenyl) 3 (alpha phenylhydrazoacetonitrilo) 1,2,4 triazine
,
4 phenylamino 6 (4 methoxyphenyl) 3 [alpha (3 cyano 2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiopene)acetonitrilo] 1,2,4 triazine
,
alpha benzal 4 methoxy omega hydrazinoacetophenone cyanoacetylhydrazone
,
alpha benzal 4 methoxy omega phenylhydrazinoacetophenone cyanoacetylhydrazone
,
ethyl 4 amino 5 h 6 (4 methoxyphenyl) 3 [alpha (2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiophene 3 carboxylate)acetonitrilo] 1,2,4 triazine
,
ethyl 4 phenylamino 6 (4 methoxyphenyl) 3 [alpha (2 hydrazo 4,5,6,7 tetrahydrobenzo[b]thiopen 3 carboxylate)acetonitrilo] 1,2,4 triazine
,
hydrazine derivative
,
hydrazone derivative
,
imipramine
,
indometacin
,
unclassified drug
,
analgesic activity
,
animal experiment
,
antidepressant activity
,
article
,
controlled study
,
cyclization
,
drug determination
,
drug mechanism
,
drug megadose
,
drug potency
,
drug screening
,
drug structure
,
drug synthesis
,
experimental mouse
,
female
,
forced swimming test
,
low drug dose
,
male
,
motor activity
,
mouse
,
nonhuman
,
sedation
Abstract:
The reaction of cyanoacetylhydrazine (1) with ?-bromo(4-methoxyacetophenone) (2) gave the hydrazide-hydrazone derivative 3. Compound 3 reacted with either potassium cyanide or potassium thiocyanide to give the cyanide or thiocyanide derivatives 4a or 4b respectively. The reaction of compound 3 with either hydrazine hydrate or phenylhydrazine gave the hydrazine derivatives 6a or 6b respectively. The latter compounds underwent a series of heterocyclization when react with different reagents to give 1,3,4-triazine and pyridine derivatives. The antidepressant, sedative and analgesic activities of the newly synthesized products were evaluated.
Show full item record