Adiponectin and E-selectin concentrations in relation to inflammation in obese type 2 diabetic patients with coronary heart disease(s)
El-Mesallamy H.O.; Hamdy N.M.; Salman T.M.; Mahmoud S.
Date issued:
2011
Series Info:
Minerva Endocrinologica
36
Type:
Article
Keywords:
Adiponectin
,
Coronary diseases
,
Diabetes mellitus
,
Obesity
,
adiponectin
,
C reactive protein
,
endothelial leukocyte adhesion molecule 1
,
glucose
,
hemoglobin A1c
,
insulin
,
interleukin 1beta
,
lipid
,
monocyte chemotactic protein 1
,
nitric oxide
,
adipose tissue
,
adult
,
article
,
atherogenesis
,
atherosclerosis
,
blood vessel injury
,
controlled study
,
diabetic obesity
,
disease association
,
glucose blood level
,
human
,
inflammation
,
insulin resistance
,
insulin sensitivity
,
ischemic heart disease
,
major clinical study
,
male
,
non insulin dependent diabetes mellitus
,
oxidative stress
,
vasculitis
,
Adiponectin
,
Adult
,
Algorithms
,
Biological Markers
,
Body Mass Index
,
C-Reactive Protein
,
Case-Control Studies
,
Chemokine CCL2
,
Coronary Disease
,
Diabetes Mellitus, Type 2
,
E-Selectin
,
Glucose Intolerance
,
Humans
,
Inflammation
,
Insulin Resistance
,
Interleukin-1beta
,
Male
,
Middle Aged
,
Obesity
,
Predictive Value of Tests
,
Sensitivity and Specificity
Abstract:
Aim. Adipose tissue is now regarded as a source of proinflammatory mediators which may contribute to vascular injury, insulin resistance (IR), and atherogenesis, however, some of them have a protective role against vascular inflammation and/or IR; namely adiponectin and nitric oxide (NO). Adiponectin is a fat derived hormone, which enhances insulin sensitivity. In experimental studies adiponectin was shown to have anti-atherogenic properties by suppressing endothelial expression of adhesion molecules as endothelial-selectin (E-selectin) and inflammatory cytokines as high-sensitivity C-reactive protein (hsCRP), interleukin-1? (IL-1?), and monocyte chemotactic protein-1 (MCP-1). Therefore, the aim of the study was to evaluate plasma adiponectin, E-selectin, hsCRP, IL-1?, and MCP-1 concentrations in obese patients with and without coronary heart disease (CHD) having type 2 diabetes mellitus (DM) and evaluation of their relationship with selected anthropometric, biochemical, and clinical parameters. Methods. The study group consisted of (N.=70) males, 20 of which served as healthy non-obese controls (group I) (mean age 38.53.7 years; mean BMI 28 1.2 kg/m2). Patients enrolled in the study were classified into the following groups: type 2 DM obese subjects without CHD (group II) (N.=25) (mean age 42.23 years; mean BMI 32.11.4 kg/m2) and type 2 DM obese subjects with CHD (group III) (N.=25) (mean age 40.63 years; mean BMI 31.51.2 kg/m 2). Glucose and insulin estimation was performed and insulin resistance index (HOMA-IR) was calculated. In the fasting state, the plasma HbA1c, adiponectin, E-selectin, in comparison to hsCRP, IL-1?, MCP-1, and lipid parameters were estimated. Results. FBG, HbA 1c%, lipids, insulin, MDA, NO, hsCRP, IL-?, MCP-1, Adiponectin as well as E-selectin concentration were significantly different in patients with type 2 DM and CHD in comparison to patients without CHD and moreover, the healthy control group (P=0.01). There was a significant negative correlation between adiponectin and E-selectin (r=-0.642; P=0.0001). Conclusion. Our study supports the hypothesis that decreased level of adipokine(s), together with increased oxidative stress, pro-inflammatory marker(s) as well as endothelial adhesion molecule(s) contributes to the complex process of atherosclerosis in type 2 diabetic obese patients that may lead eventually to CHD.
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