Up-regulation of Notch-1 in psoriasis: An immunohistochemical study
Abdou A.G.; Maraee A.H.; Sharaf A.; Elnaidany N.F.
Date issued:
2012
Series Info:
Annals of Diagnostic Pathology
16
Type:
Article
Keywords:
Immunohistochemistry
,
Notch-1
,
Psoriasis
,
PUVA
,
Notch1 receptor
,
psoralen
,
adult
,
article
,
chronic disease
,
clinical article
,
controlled study
,
correlation analysis
,
disease exacerbation
,
epidermis
,
female
,
human
,
immunohistochemistry
,
male
,
priority journal
,
protein expression
,
Psoriasis Severity Index
,
psoriasis vulgaris
,
PUVA
,
skin biopsy
,
upregulation
,
Adolescent
,
Adult
,
Aged
,
Child
,
Female
,
Humans
,
Immunohistochemistry
,
Male
,
Middle Aged
,
Psoriasis
,
PUVA Therapy
,
Receptor, Notch1
,
Skin
,
Up-Regulation
,
Young Adult
Abstract:
The Notch pathway plays a key role in differentiation, proliferation, and influencing cell fate decision in multiple organisms and tissues including the epidermis and its appendages. The role of Notch-1 in psoriasis has not been widely evaluated; therefore, the current study aimed to evaluate its role in etiopathogenesis of this common skin disease. The current study used immunohistochemical technique to evaluate Notch-1 expression in 35 lesional biopsies of patients having chronic plaque psoriasis in comparison with normal skin biopsies, representing the control group. Notch-1 was expressed in the epidermis of both normal and psoriatic skins; however, the intensity was in favor of psoriatic lesion, and the nuclear form of Notch-1 was more frequently and diffusely seen in psoriasis. Exacerbation of psoriasis as assessed by the Psoriasis Area and Severity Index score was significantly associated with intense (P =.005) and nuclear form of Notch-1 expression (P =.0001). The nuclear form of Notch-1 was also correlated with female sex (P =.043). From this study, up-regulation and not down-regulation of Notch-1 may have a role in pathogenesis of psoriasis. The nuclear form is responsible for the exacerbation of symptoms, and it is the one that may disappear by the effect of psoralen and ultraviolet A radiation (PUVA) therapy. � 2012 Elsevier Inc.
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