Abstract:
Structure-based design, synthesis and biological evaluation of newly synthesized small molecules anti-cancer
agents were described. On continuation of applying scaffold hopping theory, a series of substituted 2-amino, 3-
cyanothiophene based on the structural features of Sorafenib was designed, synthesized and evaluated as cytotoxic
agents against MCF7 and HCT 116 cell lines. Substituting the amino group of 2-aminothiophene with different
pharmacophoric groups led to discovery of two potent lead compounds IIIb and IIIc with excellent cytotoxic
activity against MCF7 and HCT 116 cell lines.
