Abstract:
Paracetamol (PAR), pseudoephedrine hydrochloride (PSE)and brompheniramine maleate (BRM) are co-formulated drugs that are widely used in the Egyptian market for the reliefof symptoms associated with common cold. Their severely overlapped spectra were resolved by two simple,accurate and precise chemometric techniques, principal component regression method (PCR) and partial Least Squares methods(PLS).The proposed methods were rapid, cost effective and were successfully applied for the analysis of laboratory prepared mixtures andthecombined dosage form. Good recoveries were obtained for PCR method, 100.42, 100.05 and 98.96%and for PLS method 100.04, 99.95 and 100.36%for PAR, PSE and BRM, respectively. Themethods were validated according to the ICH guidelines. Comparison of the applied methods with the reportedmethod was done and no significant difference was found regardingaccuracy and precision
